Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes

By P. Bousso, Ellen Robey. Nature Immunology, 2003

679 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/abff665179b601370f40bb6dce6a66a20ac9e27c

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In Immunology

Citations in the corpus

The Two Faces of IL-6 in the Tumor Microenvironment (2014, background): “This is a highly efficient process such that under resting conditions, 500–5,000 T cells scan DC every hour [68].”
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice (2006, background): “Other TPLSM studies have shown the highly dynamic nature of T cell activity in antigen-draining lymph nodes after exposure of mice to nominal antigen in adjuvant- or antigen-pulsed mature DC”
Homing and cellular traffic in lymph nodes (2003, result): “This idea was recently substantiated in another multi-photon study of excised LNs by Bousso and Robe”
Visualizing dendritic cell networks in vivo (2004, methodology): “Two-photon microscopy has been used to study mature DCs actively participating in immune responses in explanted intact lymph nodes or surgically exposed lymph nodes in anaesthetized mic”
Immunological mechanisms of vaccination (2011, background): “In the third phase, the activated T cells separate from the DCs, rapidly divide and undergo transient interaction with further DC”
The who, how and where of antigen presentation to B cells (2009, background): “The first surprising observation from these multiphoton microscopy studies was the highly motile nature of lymphocytes within the resting lymph nod”
Dendritic-cell-based therapeutic cancer vaccines. (2013, background): “Naive CD8+ T cells differentiate into CTLs in lymphoid organs upon encounter with DCs presenting tumor-derived peptides (Bousso and Robey, 2003) (Figure 2) in the context of costimulation through CD80, CD70, and 4-1BB (Shuford et al., 1997), as well as DC-derived cytokines such as IL-12 and IL-15…”
Intracellular signalling controlling integrin activation in lymphocytes (2005, background): “After encountering APC-presented cognate antigen in vivo , T cells undergo distinct changes in their adhesion pattern”
CD8+ T Cells: Foot Soldiers of the Immune System (2011, neutral): “Subsequent to injection of peptide-loaded dendritic cells (DCs), T cells scan the HEV-associated DC forming antigen-specific contacts with the DCs, leading to T cell activation (Bousso and Robey, 2003; Mempel et al., 2004; Miller et al., 2003).”