Homing and cellular traffic in lymph nodes

By Ulrich H. von Andrian, T. Mempel. Nature reviews. Immunology, 2003

1,377 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/435b722d6aa4c012641028ff0c78e3ec097796cc

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In Immunology

1. N. Restifo
2. S. Rosenberg
3. A. Luster
4. F. Sallusto
5. A. Lanzavecchia
6. J. Cyster
7. J. Schenkel
8. D. Masopust

Citations in the corpus

• Orchestrating the orchestrators: chemokines in control of T cell traffic (2008, background): “T cells can then be recruited to a different SLO, such as the spleen, Peyer's patches or other lymph node”
• Mammalian Krüppel-Like Factors in Health and Diseases (2010, background): “KLF2 accomplishes these activities by directly activating expression of CD62L (L-selectin) (16), a receptor required for T cells to enter lymphoid nodes (439), and SIP1 (51), which allows T cells to exit the thymus (266).”
• Lymphoid neogenesis in chronic inflammatory diseases (2006, background): “It remains to be determined whether TLOs also lack the intricate canalicular system of conduits and corridors that, in SLOs, regulate lymph flow and the traffic of antigen-presenting cells, lymphocytes and low-molecular-weight molecules, including chemokines, to distinct areas of the lymphoid tissu”
• Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement (2006, methodology): “The development of methods for high resolution intravital imaging of lymphoid (50, 51) and other tissue sites (52–55) has begun to reveal how immune cells move, interact, and respond in situ, adding to our understanding of normal and pathological immune events.”
• Finding a way out: lymphocyte egress from lymphoid organs (2007, background): “S1P 1 and lymphocyte egress The entry of lymphocyte into lymphoid organs involves the expression of a combinatorial array of selectins, chemokine receptors and integrins, but only one requirement for egress has been identified so fa”
• Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells (2007, background): “SLOs are the sites where primary immune responses are initiate”
• Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells. (2005, result): “Consistent with findings of others (25, 26), we found that CD62Lhigh T cells preferentially homed to lymph nodes.”
• Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming (2004, background): “After initial tethering and rolling via L-selectin, T cells require triggering of CCR7 by CCL21 expressed on HEVs and activation of lymphocyte function–associated antigen-1 for firm adhesio”
• CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract (2004, background): “Peripheral LNs are structurally organized to promote interaction between antigens, chemokines, growth factors, and lymphocytes to generate an immunologic response and maintain populations of CD4 and CD8 T cells (52).”