Visualizing dendritic cell networks in vivo

By Randall L. Lindquist, G. Shakhar, Diana Dudziak, Hedda Wardemann, Thomas R. Eisenreich, Michael Loran Dustin, Michel C. Nussenzweig. Nature Immunology, 2004

845 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/eb8aed725f49db252e279328a2290f514c1bf4c9

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Citations in the corpus

• CD8+ T Cells: Foot Soldiers of the Immune System (2011, neutral): “In naive mice, CD8 + T cells mainly reside in the T cell zones while the DCs form an extensive network throughout the T cell zone, B cell follicle, and some areas of the subcapsular sinus (Lindquist et al., 2004).”
• Dendritic cells: translating innate to adaptive immunity. (2006, background): “In contrast, the network of DCs in the T cell area continually form and retract processes but do not move translationally [66], much as was observed ex vivo when DCs were discovered more than 30 years ago [73].”
• The who, how and where of antigen presentation to B cells (2009, result): “Interestingly, similar investigations have offered insight into the behaviour of CD11c + DCs in the paracorte”
• Immunological mechanisms of vaccination (2011, background): “DCs are also positioned along the same FRC network, thus enhancing the probability of interaction with T cell”
• Interactions between programmed death-1 and programmed death ligand-1 promote tolerance by blocking the T cell receptor-induced stop signal (2009, background): “This CD11c-YFP mouse allows tracking of the in vivo movements of CD11c + DC”
• Goblet cells deliver luminal antigen to CD103+ DCs in the small intestine (2012, background): “Confocal microscopy revealed that dextran columns were a subset of epithelial cells containing intracellular dextran, which had a continuous border of e-cadherin on their basolateral surface and were often in contact with yellow fluorescent protein (YFP + ) cells in the LP of CD11c-YFP reporter mic”
• Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming. (2006, background): “Indeed, it has been argued that this is the role of inter-DC transfer, to increase priming efficiency by spreading antigen over the wider DC pool (Lindquist et al., 2004).”
• Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, positive): “In accordance with previous studies (Lindquist et al., 2004), we found that cells with a computed displacement of less than 2 μm/minutes were virtually non-migratory when observed directly, and that their pseudomigration was a result of motion artifacts.”
• Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells (2005, background): “Furthermore, although much has recently been discovered about the properties of T cell–DC interactions [14,16–18,20,21], no information is yet available on the dynamics of B-T interactions during T cell–dependent antibody responses.”