Immunological mechanisms of vaccination

By Bali Pulendran, Rafi Ahmed. Nature Immunology, 2011

1,036 citations recorded by the source corpus.

Vaccines represent one of the greatest triumphs of modern medicine. Despite the common origins of vaccinology and immunology more than 200 years ago, the two disciplines have evolved along such different trajectories that most of the highly successful vaccines have been made empirically, with little or no immunological insight. Recent advances in innate immunity have offered new insights about the mechanisms of vaccine-induced immunity and have facilitated a more rational approach to vaccine design. Here we will discuss these advances and emerging themes on the immunology of vaccination.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/9fa881aac6bfd63efe59c408879b63ae8d700c5d

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Citations in the corpus

Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies. (2014, background): “different pathogens [25].”
Systems Biology of Seasonal Influenza Vaccination in Humans (2011, background): “Two exciting new developments are beginning to offer such an understanding: the increasing appreciation of the key roles played by the innate immune system in sensing vaccines and tuning immune responses, and emerging advances in systems biology 44 .”
Dendritic-cell-based therapeutic cancer vaccines. (2013, background): “Preventive vaccines are designed to block the spread of infection, and their activity correlates with the induction of specific antibodies and long-livedmemory B cells (Pulendran and Ahmed, 2011).”