The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation

By Diego Pasini, A. Bracken, J. Hansen, M. Capillo, K. Helin. Molecular and Cellular Biology, 2007

723 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/abdb023a35d9ff57112650b9ed7bdee40b7ed858

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Citations in the corpus

A double take on bivalent promoters. (2013, background): “Likewise, Suz12 / ES cells show higher expression of lineage-specific genes (Pasini et al. 2007).”
PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes (2012, background): “Mole (Pasini et al., 2007; Schoeftner et al., 2006; Trojer et al., 2011).”
Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. (2010, neutral): “…Ezh2, Suz12, Eed, or Ring1b leads to a loss of H3K27me3 and H2AK119ub1 marks, a spontaneous increase in developmental gene expression, and consequently, differentiation defects of embryonic stem cells (Chamberlain et al., 2008; Pasini et al., 2007; Shen et al., 2008; van der Stoop et al., 2008).”
Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells (2009, background): “Once they make a commitment to differentiate, they must repress pluripotent regulators, e.g., Oct4, Nanog, and Sox2, and this process also appears to be governed either indirectly or directly by PcG-mediated events (Pasini et al., 2007).”
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. (2008, background): “, 2006), and differentiating stem cells (Pasini et al., 2007), which, however, could not be placed in the developmental history of the studied cell types.”
Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation (2014, background): “…been challenged by a series of observations in mammals demonstrating that PRC1 occupancy and H2AK119ub1 can be achieved in the absence of PRC2 (Pasini et al., 2007; Schoeftner et al., 2006; Tavares et al., 2012) and observations in Drosophila suggesting that H3K27me3 is not sufficient to…”
Distinct Epigenomic Landscapes of Pluripotent and Lineage-committed Human Cells (2010, background): “Knockout studies of H3K9 methyltransferases and H3K27 methyltransferases lead to differentiation or developmental defects (Dodge et al., 2004; Faust et al., 1998; O’Carroll et al., 2001; Pasini et al., 2007; Peters et al., 2001; Tachibana et al., 2002), suggesting that epigenetic mechanisms play a c”
Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains (2008, result): “The view that transcriptional status is upstream of PcG status in ES cells is consistent with the subtle transcriptional changes evident in PcG-deficient ES cells [9,54].”
Polycomb group proteins: navigators of lineage pathways led astray in cancer (2009, positive): “Initial studies have established that the PcG proteins are displaced from certain target genes, for example the homeobox (Hox) genes , on their transcriptional activation during differentiatio”
Global transcription in pluripotent embryonic stem cells. (2008, background): “For example, the polycomb group gene Suz12 (an H3K27 HMT) was downregulated following differentiation and was shown to play a role in ESC maintenance (Pasini et al., 2007).”
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. (2008, background): “Lastly, PRC2 binding to DNA regulatory elements could act positively to recruit specific transcription activators to initiate lineage commitment but repress transcription during terminal differentiation (Pasini et al., 2007).”