Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.

By Fabio Mohn, Michael Weber, M. Rebhan, Tim C. Roloff, J. Richter, Michael B. Stadler, M. Bibel, Dirk Schübeler. Molecules and Cells, 2008

938 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/eec6080d9041ea9b6bc22e63545fb5f369e170de

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Citations in the corpus

DNA Methylation and Its Basic Function (2013, background): “Beyond imprinted genes, DNA methylation of CpG islands regulates gene expression during development and differentiation (Shen et al, 2007; Weber et al, 2007; Fouse et al, 2008; Mohn et al, 2008; Meissner et al, 2008).”
Targets and dynamics of promoter DNA methylation during early mouse development (2010, neutral): “Pluripotency genes are preferential targets for promoter DNA methylatio”
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (2010, background): “, a modification associated with gene repression in developmen”
Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains (2008, background): “Bivalent domains and PcG target sites have been shown previously to correlate with CG-rich DNA; for example, ,50% of Suz12 binding sites in human ES cells correspond to CpG islands [11,16,29].”
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation (2009, background): “Studies using ESCs suggest that bivalent modifications maintain the activation or silencing potential of critical differentiation genes (Azuara et al., 2006; Bernstein et al., 2006).”
Epigenetic regulation of neurogenesis in the adult mammalian brain (2011, background): “European Journal of Neuroscience ª 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd European Journal of Neuroscience, 33, 1087–1093 studies have implicated a critical role of DNA methylation in regulating neurogenesis (Meissner et al., 2008; Mohn et al., 2008).”
The Polycomb Complex PRC2 and its Mark in Life (2011, background): “A conservative estimation is that PRC2 targets represent at least 10p of the genes in ES cell”
DNA methylation: superior or subordinate in the epigenetic hierarchy? (2011, background): “Thus, most EZH2 target genes actually remain constitutively unmethylated throughout development.(66) Nonetheless, a number of these genes might become targets for de novo DNA methylation under pathological conditions and contribute to cancer.”
Charting histone modifications and the functional organization of mammalian genomes (2011, background): “followed H3K27me3 patterns in gene promoters during the transition of ES cells to neural progenitors and subsequently to terminally differentiated neurons, and found a progression of HCP modifications in accordance with expression state and gene potentia”
Molecular maps of the reorganization of genome – nuclear lamina interactions during differentiation (2010, background): “, 2007); (C) RNA Pol II and (D) H3K4me2 levels on promoters (Mohn et al., 2008); (E) replication timing (Hiratani et al.”