Polycomb group proteins: navigators of lineage pathways led astray in cancer

By A. Bracken, K. Helin. Nature Reviews. Cancer, 2009

610 citations recorded by the source corpus.

The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell fate decisions and how their deregulation potentially contributes to cancer. In this Review we discuss the emerging roles of long non-coding RNAs (ncRNAs) and a subset of transcription factors, which we call cell fate transcription factors, in the regulation of PcG association with target genes. We also speculate about how their deregulation contributes to tumorigenesis.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/eaf24e1958af973d3813893f00e67688887d80e8

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Citations in the corpus

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation (2014, background): “Polycomb proteins are also perturbed in a range of cancers, suggesting that the polycomb system is critical for maintenance of normal cell identity (Bracken and Helin, 2009).”
Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. (2010, neutral): “Detailed information about the biochemical characterization and recruitment of PcG complexes to target genes can be found in other recent reviews (Surface et al., 2010; Bracken and Helin, 2009; Schuettengruber and Cavalli, 2009; Simon and Kingston, 2009).”
Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put (2013, background): “The importance of dissecting PcG mechanisms is heightened by an expanding body of literature that implicates PcG machinery in gene regulatory networks gone awry in cancer cells (reviewed in Baylin and Jones, 2011; Bracken and Helin, 2009; Mills, 2010; Simon and Lange, 2008).”
Control of Embryonic Stem Cell State (2011, background): “They also include longer ncRNAs of various types, which have been implicated in recruitment of chromatin regulators such as the PcG complexes (Bracken and Helin, 2009; Guenther and Young, 2010; Surface et al., 2010; Wilusz et al., 2009; Zhao et al., 2010). miRNAs and Control of ESC Identify…”
Epigenetic antagonism between Polycomb and SWI/SNF complexes during oncogenic transformation (2010, neutral): “Proteins from the Polycomb group (PcG) contribute to epigenetically based gene silencing during development and evidence is emerging to suggest that they may serve important roles during oncogenic transformation (Bracken and Helin, 2009; Simon and Lange, 2008).”
Molecular mechanisms of long noncoding RNAs (2011, background): “…RNA molecules greater than 200 nt in length—are poorly conserved and regulate gene expression by diverse mechanisms that are not yet fully understood (Bernstein and Allis, 2005; Bracken and Helin, 2009; Faghihi and Wahlestedt, 2009; Mercer et al., 2009; Whitehead et al., 2009; Wilusz et al., 2009).”