A double take on bivalent promoters.

By P. Voigt, Wee-Wei Tee, D. Reinberg. Genes & Development, 2013

800 citations recorded by the source corpus.

Histone modifications and chromatin-associated protein complexes are crucially involved in the control of gene expression, supervising cell fate decisions and differentiation. Many promoters in embryonic stem (ES) cells harbor a distinctive histone modification signature that combines the activating histone H3 Lys 4 trimethylation (H3K4me3) mark and the repressive H3K27me3 mark. These bivalent domains are considered to poise expression of developmental genes, allowing timely activation while maintaining repression in the absence of differentiation signals. Recent advances shed light on the establishment and function of bivalent domains; however, their role in development remains controversial, not least because suitable genetic models to probe their function in developing organisms are missing. Here, we explore avenues to and from bivalency and propose that bivalent domains and associated chromatin-modifying complexes safeguard proper and robust differentiation.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/7107848c0eb1e9405a919ba44e3df5e09752e480

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Citations in the corpus

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation (2014, background): “…are sufficient to inhibit polycomb protein activity and that KDM2B/ PCGF1/PRC1 occupancy functions mainly as a sampling module to identify sites that lack transcription and facilitate initiation of a polycomb domain (Klose et al., 2013; Ku et al., 2008; Lynch et al., 2012; Voigt et al., 2013).”
Interpreting thelanguage of histone and DNA modifications (2014, background): “Genome-wide mapping studies have documented the co-occurrence of H3K4me3 (associated with active transcription) and H3K27me3 (a dominant mark of transcriptional repression) at developmental gene promoters in embryonic stem cells (defined as ‘bivalency’) [96] – the notion being that these two marks m”