Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

By A. Molofsky, R. Pardal, T. Iwashita, In-kyung Park, M. Clarke, S. Morrison. 2003

1,418 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

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In Developmental Neuroscience

In Molecular Biology

Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Bmi-1, a member of the PcG complex, is required for neural precursor maintenance in the adult SVZ through the cell-cycle inhibitor p16 (Molofsky et al., 2003).”
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. (2006, background): “These studies have recently been confirmed and extended using mouse knockout models of INK-4A and p19 ARF (31).”
Brain tumour stem cells (2006, background): “Another gene that has recently been implicated in the regulation of self-renewal of normal neural stem cell”
Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways (2011, background): “In breast CSCs, Bmi-1, a transcriptional repressor of polycomb group of transcription factors, and known to be a key regulator of the self-renewal of normal and leukemic stem cell”
An essential switch in subunit composition of a chromatin remodeling complex during neural development. (2007, background): “Bmi-1, a member of the Polycomb-group gene (PcG) chromatinremodeling family was recently shown to be essential for the long-term maintenance/self-renewal of both neural (Molofsky et al., 2003) and hemopoietic stem cells (Lessard and Sauvageau, 2003; Park et al.”
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later (2015, background): “For example, Bmi-1, a member of the polycomb group of chromatin remodeling factors, is critical for SVZ NSC self-renewal (Molofsky et al., 2003).”
Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells (2010, background): “Mice that lack Sonic hedgehog [61], Tlx [62], Bmi1 [63,64], and Mbd1 [33] have all exhibited profound deficits in postnatal neurogenesis, but not in their embryonic neural development.”
Autoantibody signatures in prostate cancer. (2005, background): “Of note, three of the remaining 17 discriminating clones represented an epitope encoded by overlapping sequence from the 5' un-translated region (UTR) of the BMI1 gene (5'-UTR_BMI1), which is a Polycomb Group (PcG) protein implicated in various cellular processes including self-renewal.(23,24) Coinc”
For the long run: maintaining germinal niches in the adult brain. (2004, background): “(Molofsky et al., 2003) or TLX (Shi et al., 2004) have 451, 170–188. decreased proliferation of postnatal or adult neural stem Molofsky, A.V., Pardal, R., Iwashita, T., Park, I.K., Clarke, M.F., andcells without having severe embryonic neural histogenic Morrison, S.J. (2003).”
Stems cells and the pathways to aging and cancer. (2008, background): “, 2003), neural stem cells (NSCs) (Molofsky et al., 2003), and leukemic stem cells (LSCs) (Lessard and Sauvageau, 2003).”