Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells.

By Suling Liu, G. Dontu, I. Mantle, Shivani H. Patel, N. Ahn, Kyle W. Jackson, Prerna Suri, M. Wicha. Cancer Research, 2006

1,302 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/168a9a7f816b6dd4cc485af28fce44e83bbaed8e

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Citations in the corpus

Targeting the Hedgehog pathway in cancer (2006, background): “Similarly, Hh stimulation in culture increased the number and size of mammary stem-cell aggregates (referred to as mammospheres), whereas cyclopamine had the opposite effec”
The epithelial-mesenchymal transition generates cells with properties of stem cells. (2008, neutral): “Our own studies (Liao et al., 2007) and those of others (Liu et al., 2006; Moraes et al., 2007) have demonstrated that the ability to form mammospheres in vitro depends on the presence of self-renewing, gland-reconstituting stem cells within the population.”
Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation (2008, background): “Finally, although a clear relationship between the niche and gene silencing mediated by Polycomb group (PcG) proteins (see below) has not been demonstrated, the morphogen Hedgehog has been shown to induce the expression of Bmi1 , which encodes a Polycomb-complex protein, and stimulate mammary s”
Molecular definition of breast tumor heterogeneity. (2007, background): “In vitro clonogenicity studies suggest the existence of bipotential progenitors that can give rise to both luminal epithelial and myoepithelial cells, lineage-restricted luminal epithelial and myoepithelial progenitors, and differentiated luminal epithelial and myoepithelial cells (Bocker et al., 20”
Transient Low Doses of DNA Demethylating Agents Exert Durable Anti-tumor Effects on Hematological and Epithelial Tumor Cells (2012, neutral): “Liu et al., 2006).”
HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion (2008, background): “These include Oct3/4 and genes involved in the Notch and Hedgehog signaling pathways (Dontu et al., 2004; Liu et al., 2006; Tokuzawa et al., 2003).”
Modelling breast cancer: one size does not fit all (2007, methodology): “For example, this technology has been used to investigate tumour-initiating properties and to identify critical signalling pathways, including BMI1 (a ring-finger polycomb group protein) and Hedgehog, that regulate the self-renewal of subpopulations derived from breast cancer”
Beyond tumorigenesis: cancer stem cells in metastasis (2007, background): “Bmi-1 is also required for neural stem cell selfrenewal and is highly expressed in brain tumor CSCs [35, 44, 45 ].”
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. (2007, background): “Primers used in the RT-PCRs were as follows: IL-6, annealing temperature 62°C, amplicon length 170 bp, forward 5′-GAGAAAGGAGACATGTAACAAGAGT-3′, reverse 5′-GCGCAGAATGAGATGAGTTGT-3′; Notch-3, annealing temperature 62°C, amplicon length 93 bp, forward 5′-TCAGGCTCTCACCCTTGG-3′, reverse 5′-AGTCACTGGCACGG”
Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer—How We Can Rise to the Challenge (2019, background): “Both GLI1 and GLI2 are upregulated in breast CSCs, while the induction of cell differentiation considerably reduced their expression [94,95].”