Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins

By R. Zenz, R. Eferl, L. Kenner, L. Florin, Lars Hummerich, D. Mehić, H. Scheuch, P. Angel, E. Tschachler, E. Wagner. Nature, 2005

622 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/a80c902e66e92918ac66945f410dcaf0de36e0c4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. M. Karin
2. T. Lawrence
3. V. Nizet
4. Hiroshi Takayanagi
5. Frank O. Nestle
6. M. Bianchi
7. P. Di Meglio
8. N. Perkins

In Molecular Biology

1. M. Karin
2. T. Lawrence
3. A. Piccinini
4. K. Midwood
5. Hiroshi Takayanagi
6. M. Bianchi
7. R. Medzhitov
8. N. Perkins

In Oncology

1. T. Lawrence
2. V. Nizet
3. M. Karin
4. Hiroshi Takayanagi
5. N. Perkins
6. Bharat B. Aggarwal
7. S. Grivennikov

Citations in the corpus

• Skin immune sentinels in health and disease (2009, background): “Moreover, mice with targeted deletion of JUN and JUNB (both components of the transcription factor AP1) in keratinocytes spontaneously developed chronic inflammation in the skin and joints, with some features resembling psoriasis and psoriatic arthriti”
• DAMPening Inflammation by Modulating TLR Signalling (2010, background): “• Atherosclerosis [264] • Inflammatory bowel disease [265, 266] • Lupus [267] • Psoriasis [268] • Rheumatoid arthritis [269-271] • Sepsis [140] • Systemic sclerosis [120] • Tumors inc breast, lung, pancreatic, colorectal,”
• Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. (2006, background): “…of T and B lymphocytes, which are believed to be important contributors to the maintenance of psoriasis and RA (Feldmann and Maini, 2003), suppressed development of psoriatic lesions less than deletion of TNFR1 but still attenuated the development of subsequent arthritis (Zenz et al., 2005).”
• DAMPs, PAMPs and alarmins: all we need to know about danger (2007, background): “S100s may be involved in arthritis [31, this issue] and psoriasis [ 50 ].”
• S100A8 and S100A9 in inflammation and cancer. (2006, background): “[71] Zenz R, Eferl R, Kenner L, Florin L, Hummerich L, Mehic D, et al.”
• Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems (2007, background): “, but emerging evidence indicates that they also have an unexpectedly interesting role in the immune system (for example, the role of FOS in lipopolysaccharide signalling”