Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

By Hiroshi Takayanagi. Nature reviews. Immunology, 2007

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Macrophage heterogeneity in tissues: phenotypic diversity and functions (2014, background): “In addition to their conventional role in bone resorption, osteoclasts regulate the differentiation of osteoblast precursors, the movement of hematopoietic stem cells from the bone marrow to the bloodstream and overall immune response (59).”
Inflammation, Fracture and Bone Repair (2016, background): “Osteoprotegerin (OPG), a soluble decoy receptor produced by B cells, dendritic cells, MSCs, and osteoblasts, can block these effects through competitive bindingwith RANKL [77,81].”
Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015, background): “Together, these factors promote the activation of transcription factors [81, 82] and gene expression in osteoclasts [83, 84].”
Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. (2012, positive): “The negative influence of inflammation on bone reflects the tight interactions between the immune system and the skeleton, which have recently lead to a new research field termed osteoimmunology (12).”