S100A8 and S100A9 in inflammation and cancer.

By C. Gebhardt, J. Nemeth, P. Angel, J. Hess. Biochemical Pharmacology, 2006

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Nutritional immunity beyond iron: a role for manganese and zinc (2009, background): “Calprotectin is a heterodimer of S100A8 and S100A9 that accounts for 40–50% of the protein constituent of the neutrophil cytoplasm [47].”
A CXCL1 paracrine network links cancer chemoresistance and metastasis (2012, positive): “S100A8/9 are low molecular weight calcium binding proteins that are associated with chronic inflammation and cancer (Gebhardt et al., 2006 À/À bone marrow showed a marked increase in the number of apoptotic cells in the mammary tumors and the lung (Figure 4A).”
Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells (2008, background): “Up-regulation of S100A8/A9 in various tumors (17), their positive autocrine secretion, and promotion of a feed forward loop involving receptors such as RAGE suggest that these proteins play an important role in inflammation mediated cancer progression.”
Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer (2009, background): “They are elevated in patients with a variety of inflammatory diseases (92, 93) where they amplify inflammation by chemoattracting leukocytes that produce additional proinflammatory mediators (94).”