The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes.

By Lijun Sun, L. Deng, Chee-Kwee Ea, Zong-Ping Xia, Zhijian J. Chen. Molecules and Cells, 2004

731 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a557ca4d4d3d88952dabb89e3e8a74d2fadd6715

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In Cancer Research

1. Shizuo Akira
2. S. Ghosh
3. M. Hayden
4. Taro Kawai
5. N. Perkins
6. M. Karin
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8. K. Takeda

In Immunology

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2. S. Ghosh
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In Molecular Biology

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4. Taro Kawai
5. N. Perkins
6. V. Dixit
7. T. Mogensen
8. Zhijian J. Chen

Citations in the corpus

• Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “Thus, molecular signaling mechanisms within the TRIF-dependent pathway illustrate how selective binding of different molecules, i.e., either TRAF3 or TRAF6, results in recruitment and downstream activation of TBK1-IRF versus TAK1-IKK-NF- B, respectively (Fig.”
• Regulation and Function of IKK and IKK-Related Kinases (2006, background): “TRAF6 and TRAF2, whose roles were thought to be limited to IL-1R and TNFR signaling, were recently suggested to be also involved in TCR-mediated activation of IKK (145).”
• Ubiquitylation in innate and adaptive immunity (2009, background): “MALT1 contains binding sites for both TRAF2 and TRAF6, and recruitment of TRAF6 to the CBM complex induces the E3 ligase activity of TRAF6 by promoting its oligomerizatio”
• Phosphorylation of the CARMA1 Linker Controls NF-κB Activation (2005, methodology): “This drives a conformational change resulting in: (1) the coassociation of the CARMA1 CARD domain with a Bcl10/MALT1/Traf/ Ubiquitin complex (Bertin et al., 2001; Gaide et al., 2001; Sun et al., 2004); (2) association of IKKg (and the associated IKK complex) with the SH3 and/or PDZ domains of CARMA1”
• NF-κB and the immune response (2006, background): “This ubiquitination event appears to be mediated by MALT1, and perhaps TRAF6, although no TCR signaling deficits have been reported in TRAF6-deficient mice (Lomaga et al., 1999; Sun et al., 2004).”
• Signaling in innate immunity and inflammation. (2012, background): “BCL10 engages TRAF6 in lymphocytes to activate NF-kB (Sun et al. 2004b), and a similar pathway may operate downstream from MAVS.”
• Essential function for the kinase TAK1 in innate and adaptive immune responses (2005, background): “It has also been proposed that TAK1 is involved in T cell receptor signaling downstream of TRAF6 to activate NF-κ”
• Essential role for IκB kinase β in remodeling carma1-bcl10-malt1 complexes upon T cell activation (2006, neutral): “TCACTGTGTTACTGGATGA-3’ ( Sun et al., 2004 ), Bcl10: 5’-”
• Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway (2006, background): “…al. (2003a) K285 Ubiquitination (K63 linked) NOD2/RIP2 Activation Abbott et al. (2004) K399 Ubiquitination (K63 linked) Bcl10/Malt/TRAF6 Activation Sun et al. (2004), Zhou et al. (2004) aa397-417 Ubiquitination (K6 linked) Not known Activation Tang et al. (2003) IKKb S177 and S181 Phosphorylation…”
• Ubiquitin signalling in the NF-κB pathway (2005, background): “Two studies have shown that BCL10 and MALT1 induce the Lys 63-linked polyubiquitination of NEMO by UBC13/UEV1A, leading to IKK activatio”