Regulation and Function of IKK and IKK-Related Kinases

By Hans Häcker, M. Karin. Science's STKE, 2006

1,359 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/c13aa76d492370f9a63be2480b4fb5e46b237478

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. S. Ghosh
2. M. Hayden
3. M. Karin
4. Shizuo Akira
5. Taro Kawai
6. Andrea Oeckinghaus
7. T. Mogensen
8. V. Nizet

In Immunology

1. S. Ghosh
2. Shizuo Akira
3. M. Hayden
4. M. Karin
5. Taro Kawai
6. T. Mogensen
7. Guido Kroemer
8. Andrea Oeckinghaus

Citations in the corpus

• Oxidative Stress and Oxidative Damage in Carcinogenesis (2010, background): “Degradation of IkB proteins allows the entry of NF-kB into the nucleus where it binds kB-regulatory elements (Hacker and Karin 2006).”
• Interdependence of hypoxic and innate immune responses (2009, background): “NF-κB activity is controlled by inhibitor of NF-κB (IκB) kinases (IKKs), mainly IKKβ, which carry out the phosphorylation-dependent degradation of IκB inhibitors in response to infectious or inflammatory stimul”
• NF-κB, the first quarter-century: remarkable progress and outstanding questions. (2012, background): “CARD, and DD-containing protein to promote IKK activation in response to genotoxic stress (Janssens et al. 2005; Hacker and Karin 2006).”
• Molecular mechanisms of necroptosis: an ordered cellular explosion (2010, background): “) These receptors usually activate the apoptotic machinery, and their cytotoxicity often requires the presence of transcriptional or translational inhibitors, suggesting the existence of short-lived cytoprotective proteins that are continuously being synthesized (reviewed in Ref”
• Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023, background): “447,448 Furthermore, the reduction of mHTT levels with siRNA improved NF-kB transcriptional dysregulation and reduced pro-in fl ammatory cytokine production in HD. 449 Kynurenine pathway metabolic balance in fl uences the function of microglia in HD. Kynurenine 3-monooxygenase (KMO) enzyme, which is…”
• NF‐κB and the link between inflammation and cancer (2012, background): “This ternary complex normally functions in activating IKK- NF-jB downstream of antigen receptors (92, 93).”
• Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “NEMO appears to function as a signal integrator in the NF- B pathway by receiving and transmitting converging signals from various stimuli and pathways to common downstream signaling events (112, 244, 311, 397).”
• Crosstalk in NF-κB signaling pathways (2011, background): “TBK1 or IKKe then phosphorylates the interferon-response factors IRF3 and IRF7, which results in the transcription of genes encoding type I interferon”
• Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. (2009, background): “The IKK complex, consisting of two kinases, IKKa and IKKb, and the regulatory component NEMO (also known as IKKg), is activated by an upstream kinase known as TAK1, which is in turn activated after TNF-a or IL-1 receptor stimulation (Häcker and Karin, 2006).”
• The NF-kappaB family of transcription factors and its regulation. (2009, background): “Significant progress has also been made in understanding how negative regulators influence signaling upstream of the IKK complex (Hayden and Ghosh 2004; Krappmann and Scheidereit 2005; Hacker and Karin 2006).”
• Regulation and Cellular Roles of Ubiquitin-specific Deubiquitinating Enzymes (2009, background): “However, K48-linked ubiquitination is involved as it is necessary to trigger the degradation of IκB, an inhibitor of NF-κB that retains the transcription factor in the cytoplasm, and to target the degradation of RIP1 during downregulation of the TNF signaling pathway.”