Ubiquitin signalling in the NF-κB pathway

By Zhijian J. Chen. Nature Cell Biology, 2005

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Involvement of linear polyubiquitylation of NEMO in NF-κB activation (2009, background): “Involvement of the ubiquitin system in the canonical NF-κB activation pathway has been well described previousl”
Targeting the ubiquitin system in cancer therapy (2009, methodology): “and the activation of protein kinases in the NF-κB pathway (UBDs in NEMO and TAB, reviewed in ref”
Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway (2006, background): “Ser-32/36 phosphorylation of IkBa results in binding of the SCF-bTrCP E3 ligase and a member of the UBC4/5 E2 ligase family, leading to ubiquitination of IkBa at lysines 21 and 22 (Chen, 2005; Krappmann and Scheidereit, 2005).”
Ubiquitylation in innate and adaptive immunity (2009, background): “It is believed that polyubiquitin chains linked through lysine at position 48 of ubiquitin (Lys 48) target protein substrates for degradation by the proteasome, whereas polyubiquitin chains of alternative linkages (such as Lys 63) carry out signalling functions independent of proteolysi”
Integrating cell-signalling pathways with NF-κB and IKK function (2007, background): “IKK-complex activation Numerous NF-κB-activating stimuli, which frequently engage distinct cell-surface receptors and/or cytoplasmic signalling pathways, converge on the IKK complex and induce the canonical pathwa”