Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

By H. Münzberg, J. Flier, C. Bjørbaek. Endocrinology, 2004

735 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/a3208a146b6f8e7e961a81d2b8e43186d10b222d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Bradford B. Lowell
2. M. Myers
3. C. Ye
4. M. Schwartz
5. J. Elmquist
6. G. Hotamışlıgil

In Epidemiology

1. M. Myers
2. C. D. De Souza
3. E. Araújo
4. M. J. Saad
5. L. Velloso
6. S. Bordin
7. M. Schwartz
8. R. L. Zollner

In Nutrition and Dietetics

1. Bradford B. Lowell
2. M. Myers
3. M. Schwartz
4. J. Elmquist
5. G. Hotamışlıgil

Citations in the corpus

• Obesity and Leptin Resistance: Distinguishing Cause from Effect (2010, methodology): “, LEPR-B signaling due to endogenous circulating leptin) are actually increased in DIO animals compared to chow-fed controls (23).”
• Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. (2006, positive): “Leptin Action on SF1 Neurons Promotes Resistance to Diet-Induced Obesity It has recently been reported that high-fat feeding causes leptin resistance in neurons of the ARC but not in neurons outside of the ARC, including the VMH ( Munzberg et al., 2004 ).”
• Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. (2005, background): “Recent studies have shown that ingestion of a fat-rich diet leads to hypothalamic resistance to leptin (9, 23).”
• Mechanisms of leptin action and leptin resistance. (2008, background): “The cellular leptin resistance phenotype of DIO animals is most prominently detected in the ARC relative to other hypothalamic sites (33, 102).”
• Leptin and Obesity: Role and Clinical Implication (2021, background): “A few hypothalamic areas (DMH, preoptic area (POA), paraventricular nucleus (PVN), VMH, ARC), but also some extra-hypothalamic regions as the nucleus tractus solitarius (NTS) participate in leptin-induced thermogenesis (125).”
• Cardiac remodeling in obesity. (2008, background): “Indeed, using a high-fat induced model of obesity in mice, leptin resistance measured by STAT-3 activation was shown to be restricted to the arcuate nucleus of the hypothalamus (60, 194), and this correlated with expression of the suppressor of leptin signaling SOCS-3 (248).”
• Obesity and the role of adipose tissue in inflammation and metabolism. (2006, background): “In mice that became obese after being fed a high-fat diet, leptin concentrations increased, and this increase was accompanied by an increased expression of SOCS-3 (suppressor-of-cytokine-signaling), a potent inhibitor of leptin signaling (29).”