Leptin and Obesity: Role and Clinical Implication

By M. Obradović, E. Sudar-Milovanovic, Sanja Soskić, M. Essack, S. Arya, Alan J. Stewart, T. Gojobori, E. Isenovic. Frontiers in Endocrinology, 2021

920 citations recorded by the source corpus.

The peptide hormone leptin regulates food intake, body mass, and reproductive function and plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis. Leptin is a product of the obese (ob) gene and, following synthesis and secretion from fat cells in white adipose tissue, binds to and activates its cognate receptor, the leptin receptor (LEP-R). LEP-R distribution facilitates leptin’s pleiotropic effects, playing a crucial role in regulating body mass via a negative feedback mechanism between adipose tissue and the hypothalamus. Leptin resistance is characterized by reduced satiety, over-consumption of nutrients, and increased total body mass. Often this leads to obesity, which reduces the effectiveness of using exogenous leptin as a therapeutic agent. Thus, combining leptin therapies with leptin sensitizers may help overcome such resistance and, consequently, obesity. This review examines recent data obtained from human and animal studies related to leptin, its role in obesity, and its usefulness in obesity treatment.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/3f15bfb4254c5e3a5a198139e817c7cdf53b07d8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

  1. M. Bou Zerdan
  2. Y. Bouferraa
  3. M. Bou Zerdan
  4. Sabine Allam
  5. Gracia Fahed
  6. H. Assi
  7. Lawrence Aoun

Citations in the corpus