Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis.

By H. Dhillon, J. Zigman, C. Ye, Charlotte E. Lee, Robert A. McGovern, V. Tang, Christopher D. Kenny, Lauryn M Christiansen, Ryan D. White, E. Edelstein and 6 more. Neuron, 2006

781 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/8cf3ef6ceedceafb645aa080c5501ea236c57955

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. S. O’Rahilly
2. I. S. Farooqi
3. B. Kahn
4. C. Ye
5. A. Coll
6. Bradford B. Lowell

In Nutrition and Dietetics

1. S. O’Rahilly
2. I. S. Farooqi
3. B. Kahn
4. A. Coll
5. Bradford B. Lowell
6. G. Karsenty

In Physiology

1. S. O’Rahilly
2. R. Hen
3. B. Kahn
4. Bradford B. Lowell
5. Mitchell A. Lazar

Citations in the corpus

• Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males (2013, neutral): “In contrast to the weight gain subsequent to a VMH lesion (Dhillon et al., 2006; Hetherington and Ranson, 1940; King, 2006; Majdic et al., 2002), PR females maintained body weight similar to controls upon ablation of PR+ VMHvl neurons (Figure S5I).”
• Leptin regulation of bone mass, appetite and energy expenditure relies on its ability to inhibit serotonin synthesis in the brainstem (2009, positive): “As reported previously mice lacking ObRb either in Sf1expressing neurons of the VMH nuclei or in Pomc-expressing neurons of the arcuate nuclei had normal sympathetic activity, bone remodeling parameters and bone mass; they also had normal appetite, energy expenditure and body weight (Figures 7A–7G a”
• The Hormonal Control of Food Intake (2007, positive): “Indeed, there are now clear data to show that leptin receptors on other neurons, such as those that express steroidogenic factor 1 (SF1) in the ventromedial hypothalamus, are required for normal body weight (Dhillon et al., 2006).”
• Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons (2011, positive): “, 2008) and SF1 neurons (Bingham et al., 2008; Dhillon et al., 2006).”
• Neuronal PTP1B regulates body weight, adiposity and leptin action (2006, background): “, with SF-1–expressing neurons in the ventral medial hypothalamus and other, as yet unidentified, LRb-expressing neurons also require”
• Leptin receptor signaling in midbrain dopamine neurons regulates feeding. (2006, neutral): “First, the limited effect of leptin on membrane potential is in contrast to previous reports on hypothalamic neurons ( Cowley et al., 2001; Spanswick et al., 1997) and may suggest a distinct mechanism for leptin modulation of excitability within the VTA.”