Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus.

By C. D. De Souza, E. Araújo, S. Bordin, Rika Ashimine, R. L. Zollner, A. Boschero, M. J. Saad, L. Velloso. Endocrinology, 2005

1,102 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/b2800973adc0c48abbc9ed4a4d9d1e0664aeb256

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. G. Hotamışlıgil
2. Jerrold M. Olefsky

In Epidemiology

1. G. Hotamışlıgil
2. Jerrold M. Olefsky
3. P. Calder
4. M. Rogero
5. O. Osborn
6. J. Avruch
7. M. J. Saad
8. L. Velloso

In Nutrition and Dietetics

1. M. Rogero
2. G. Hotamışlıgil
3. P. Calder
4. Jerrold M. Olefsky
5. I. Djuricić

Citations in the corpus

• Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. (2012, background): “A HFD is accompanied by increased phosphorylation of hypothalamic JNK, and local administration of a JNK inhibitor reduces food intake and restores sensitivity of insulin-induced inhibition of food intake (61).”
• Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease (2010, positive): “Early suggestions for a potential link between inflammation and metabolic regulation in the brain came from studies showing obesityinduced inflammatory alterations in the hypothalamus (De Souza et al., 2005) and reduced weight gain in JNK-deficient mice fed a high-fat diet (Hirosumi et al., 2002).”
• Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids (2018, background): “However, currently, it is known that there are other tissues involved in meta-inflammation, such as the liver [54], pancreas [55], hypothalamus [56,57], and skeletal muscle [58].”
• Immune System to Brain Signaling: Neuropsychopharmacological Implications (2011, background): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript inflammatory cytokines) in several brain areas, including the cortex and hippocampus, of animals fed a high-fat diet known to induce obesity (De Souza et al., 2005; Zhang et al., 2005).”
• Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity (2009, background): “Reversal of these effects can be achieved by distinct genetic and pharmacological approaches, aimed at inhibiting inflammatory signaling (Howard et al., 2004; De Souza et al., 2005).”
• The cellular and signaling networks linking the immune system and metabolism in disease (2012, background): “Obesity-induced inflammatory changes have also been reported in the central nervous system (CNS), including in the hypothalamu”