Cardiac remodeling in obesity.

By E. Dale Abel, S. Litwin, G. Sweeney. Physiological Reviews, 2008

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Diabetic cardiomyopathy, causes and effects (2010, background): “An increase in myocardial fatty acid uptake and oxidation has been described in humans with both Type 1 and Type 2 diabetes, as well as in many animal models [17, 23, 24].”
Effect of Obesity on the Pharmacokinetics of Drugs in Humans (2010, background): “Tissue perfusion may be reduced in obese individuals,([35,36]) and alterations in cardiac structure and function have been observed in the obese.([37]) These haemodynamic changes could potentially alter drug distribution and CL in obesity.”
Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease. (2010, background): “Physiological Reviews, 90(1), 367-417.”
Pathological Ventricular Remodeling: Mechanisms: Part 1 of 2 (2013, background): “accumulate in the heart, coupled with impaired mitochondrial function, to oxidize the increased lipid load.(135) Several molecu-”
Myocardial fatty acid metabolism in health and disease. (2010, background): “In addition, in the ob/ob mouse, protein contents of complexes I, III, and V are reduced, and isolated mitochondria have a reduced oxidative capacity (5).”