Mechanisms of leptin action and leptin resistance.

By M. Myers, M. Cowley, H. Münzberg. Annual Review of Physiology, 2008

1,098 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Genetic Loci Influencing C-reactive Protein Levels and Risk of Coronary Heart Disease (2009, neutral): “SNPrs6700896is located in intron 19 of LEPR, the gene encoding the leptin receptor, a member of theclassIcytokinereceptorfamily.(70)LEPR isexpressedinthehypothalamusandvascular endothelial cells,(71) and LEPR signaling has a role in appetite control, weight regulation,glucosehomeostasis, blood press”
Narrative Review: The Role of Leptin in Human Physiology: Emerging Clinical Applications (2010, background): “Most obese humans, however, have high circulating leptin levels (3) and are either resistant or tolerant to its weight-reducing effects (18).”
Trends in insulin resistance: insights into mechanisms and therapeutic strategy (2022, background): “Leptin-deficient mice (ob/ob) causes both obesity and diabetes due to hyperphagia and blunted metabolic rate, and treatment with exogenous leptin could prevent and reverse the obese phenotype.(152) Moreover, the decreased permeability of the brain-blood barrier (BBB) to leptin and impaired leptin si”