Intracellular NOD-like receptors in host defense and disease.

By T. Kanneganti, M. Lamkanfi, G. Núñez. Immunity, 2007

1,074 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a1013b4844dc3ab135d528dc8512f0698ce4b772

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In Immunology

1. Shizuo Akira
2. T. Kanneganti
3. M. Lamkanfi
4. T. Mogensen
5. J. Tschopp
6. G. Núñez
7. V. Dixit
8. L. Franchi

In Molecular Biology

1. T. Kanneganti
2. M. Lamkanfi
3. G. Núñez
4. Jüergen Cox
5. Shizuo Akira
6. V. Dixit
7. Matthias Mann
8. Kate Schroder

Citations in the corpus

• An update on the regulatory mechanisms of NLRP3 inflammasome activation (2021, background): “INTRODUCTION Inflammasomes are cytoplasmic high-molecular-weight protein platforms of caspase-1 activation in response to microbial invasion and damage signals.(1,2) Inflammasomes consist of the nucleotidebinding oligomerization domain (NOD)-like receptor (NLR) family, the adapter apoptosis-associat”
• Inflammasomes and their roles in health and disease. (2012, background): “PRRs enable innate immune cells to instantly detect and respond to the presence of danger- and pathogen-associated molecular patterns (DAMPs and PAMPs, respectively) (Kanneganti et al. 2007).”
• Autophagy, Immunity, and Microbial Adaptations (2009, background): “Genetic risks in CD were linked some time ago to innate immunity via Nod2, which like many other PRRs recognizes bacterial products of the enteric flora (Kanneganti et al., 2007).”
• Neutrophil cell surface receptors and their intracellular signal transduction pathways (2013, background): “Their ligation leads to ubiquitination of RICK and subsequent activation of TAK1, NF-κB and MAP-kinase pathways, triggering inflammatory cytokine production [219].”
• Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “Fever episodes seem to be triggered more or less spontaneously, possibly by subclinical viral infections or cellular stress activating the inflammasome, and the resultant IL-1 hyperproduction results in a clinical picture resembling a microbial infection (169, 233).”
• NLRP3 (NALP3/CIAS1/Cryopyrin) mediates key innate and healing responses to influenza A virus via the regulation of caspase-1 (2009, positive): “The mechanisms underlying this excessive innate response are only now being characterized, with the studies to date demonstrating roles for the pattern-recognition receptors TLR3, TLR7, and RIG-I (Diebold et al., 2004; Heer et al., 2007; Hornung et al., 2006; Kato et al., 2005; Kawai et al., 2005; K”
• Activation of innate immune antiviral response by NOD2 (2009, background): “A third class of PRR includes members of the nucleotide-binding domain (NBD)– and leucine-rich-region (LRR)–containing family of cytoplasmic proteins (known as NLRs); these proteins respond to bacterial PAMPs to activate the transcription factor NF-κB and mitogen-activated protein kinase pathway”
• The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity (2010, background): “Activation of caspase-1 itself takes place by conformational changes in a protein platform called the inflammasome, consisting of caspase-1 and proteins of the NACHT-LRR (NLR) family including NLRP3 and ASC, leading to the release of the active enzyme (Kanneganti et al., 2007).”
• Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. (2011, background): “Among TFEB direct targets are genes belonging to distinct families of pattern recognition molecules including membrane-anchored Toll-like receptors (TLRs), cytosolic Nod-like receptors (NLRs) and Rig-I-like receptors (RLRs), which are involved in innate immune detection of danger signals and microbi”
• The Multifaceted Functions of Neutrophils (2013, background): “Other signaling PRRs include the cytosolic microbial sensors NOD1 and NOD2, which recognize peptidoglycan-related molecules of gram-negative and gram-positive bacteria, respectively (77).”
• Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “It must also be mentioned that not all bacterial pathogens that invade the cytosol activate NLRP3 as Salmonella, Franciscella, and Listeria, which are capable of delivering bacterial products into the cytosol through type III secretion systems or pore-forming molecules without ATP stimulation, activ”
• Recognition of Peptidoglycan from the Microbiota by Nod1 Enhances Systemic Innate Immunity (2010, background): “This requires signaling via the pattern recognition receptor nucleotide-binding, oligomerization domain–containing protein-1 (Nod1, which recognizes meso -diaminopimelic acid ( meso DAP)-containing peptidoglycan found predominantly in Gram-negative bacteria), but not Nod2 (which detects peptidoglyc”