FACT Facilitates Transcription-Dependent Nucleosome Alteration

By R. Belotserkovskaya, Sangtaek Oh, V. Bondarenko, G. Orphanides, V. Studitsky, D. Reinberg. Science, 2003

903 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a056600c5598f8e09aebc8da8544c1d20704c267

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In Molecular Biology

Citations in the corpus

The human CENP-A centromeric nucleosome-associated complex (2006, background): “Given the previously established role of the FACT complex (which is shown here to interact with the CENP-A nucleosome) in sequestering H2A:H2B during RNA polymerase II mediated transcriptio”
The complex language of chromatin regulation during transcription (2007, background): “Furthermore, the elongation factors that suppress spurious internal start sites also facilitate nucleosome alteration during transcriptio”
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (2006, background): “The formation of a hexamer (a nucleosome depleted of one H2A/ H2B dimer) is believed to be essential for the passage of RNA polymerase II through the nucleosomal barrier (Kireeva et al., 2002; Belotserkovskaya et al., 2003).”
A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers (2010, background): “Mechanistically, transcriptional elongation causes a broad spectrum of effects to the underlying chromatin template, including chromatin remodeling, nucleosome eviction, and changes in the acetylation and methylation state of histone tails [32,33], effects that are all due to the association of mult”
Distinct activities of CHD1 and ACF in ATP-dependent chromatin assembly (2005, background): “The function of CHD1 as a chromatin assembly factor fits well with its proposed role in the reassembly of nucleosomes subsequent to their disruption during transcriptio”
The role of chromatin during transcription. (2007, background): “It was ultimately shown that FACT does act as a chaperone during transcription and that it functions in both disassembly and reassembly of H2A/ H2B dimers (Belotserkovskaya et al., 2003).”
Elongation by RNA polymerase II: the short and long of it. (2004, methodology): “FACT and Spt6 selectively interact with histone H2A/ H2B dimers and histone H3, respectively (Bortvin and Winston 1996; Belotserkovskaya et al. 2003).”
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. (2005, background): “The FACT complex and Spt6 facilitate the disassembly of nucleosomes ahead of and reassembly in the wake of the elongating polymerase (Belotserkovskaya et al., 2003).”