A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers

By Francesca De Santa, I. Barozzi, F. Mietton, S. Ghisletti, S. Polletti, B. Tusi, H. Muller, Jiannis Ragoussis, Chia-Lin Wei, G. Natoli. PLoS Biology, 2010

893 citations recorded by the source corpus.

A substantial fraction of extragenic Pol II transcription sites coincides with transcriptional enhancers, which may be relevant for functional annotation of mammalian genomes.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bcc78a945fb61dc3a80e8c661b1c63881f208167

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Citations in the corpus

Determinants of enhancer and promoter activities of regulatory elements (2019, background): “De Santa (2010) and Kim (2010) are the first studies to observe bidirectional transcription of eRNAs from candidate enhancers at large scale.”
Charting histone modifications and the functional organization of mammalian genomes (2011, background): “The function of these eRNAs is not understood, but similar findings also emerged from a study of enhancer elements in macrophage”
Latent enhancers activated by stimulation in differentiated cells. (2013, neutral): “…considered additional features known to be associated with enhancers, including increased accessibility of genomic DNA (Gross and Garrard, 1988), binding of histone acetyltransferases (HATs) (Heintzman et al., 2007), RNA Pol II, and noncoding transcription (De Santa et al., 2010; Kim et al., 2010).”
The multidimensional mechanisms of long noncoding RNA function (2017, background): “Several studies have evaluated the relationship between enhancer transcripts and gene activation (reviewed in [86]), showing that the levels of eRNAs correlate with mRNA synthesis of the neighbouring genes [51, 87].”
lincRNAs: Genomics, Evolution, and Mechanisms (2013, neutral): “…we are not suggesting that a significant number of lincRNAs can be attributed to the transcription observed within many enhancer elements (De Santa et al., 2010; Kim et al., 2010); these enhancer transcripts are not typically polyadenylated, and lincRNA genes overlap enhancers no more…”