Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice

By Gerd Kempermann, D. Gast, Golo Kronenberg, Masahiro Yamaguchi, Fred H. Gage. 2003

1,012 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

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Citations in the corpus

Human Hippocampal Neurogenesis Persists throughout Aging (2018, neutral): “As type II INPs differentiate into neuroblasts, or type III INPs, they lose the expression of Sox2 and GFAP while gaining expression of DCX and polysialylated neural cell adhesion molecule (PSA-NCAM), which is also expressed by immature and mature granule neurons (GNs) (Encinas et al., 2011).”
Dynamics of hippocampal neurogenesis in adult humans (2013, positive): “Hippocampal neurogenesis in mice and rats is additive and results in a net increase in the number of dentate gyrus neurons with age (Bayer, 1985; Imayoshi et al., 2008; Kempermann et al., 2003; Ninkovic et al., 2007).”
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. (2007, background): “It has been established that adult-born neurons in the hippocampus contribute almost exclusively to only the inner two-thirds of the granule cell layer (Figure 2A; Esposito et al., 2005; Kempermann et al., 2003).”
Computational influence of adult neurogenesis on memory encoding. (2009, positive): “In rats, thousands of new granule cells (GC) are born into the existing circuitry every day (Cameron and McKay, 2001), though only a fraction of these cells survive to become fully functional neurons (Kempermann et al., 2003).”
Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus (2004, background): “Young neurons are located in the SGZ–GCL border, and as they become older, they are displaced deeper into the GCL (Altman and Das, 1965; Altman and Bayer, 1986; Angevine, 1986; Hastings and Gould, 1999; Kempermann et al., 2003).”
GABA-CREB signalling regulates maturation and survival of newly generated neurons in the adult hippocampus (2009, background): “Neurons that have survived this period are incorporated for an extended time into the hippocampal network (Dayer et al., 2003; Kempermann et al., 2003; Kee et al., 2007; Tashiro et al., 2007).”
Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus (2007, background): “4 online), where the vast majority of BrdU + cells were locate”
Hippocampal granule cells opt for early retirement (2010, neutral): “2A and 3A; Kempermann et al., 2003, Fig.”
Synapse formation on neurons born in the adult hippocampus (2007, result): “1 ), and previous studies indicate that most newborn neurons die during the first month after cell divisio”
Learning Enhances the Survival of New Neurons beyond the Time when the Hippocampus Is Required for Memory (2004, background): “However, there is evidence that neurons that survive beyond a few weeks persist at least 11 months in the rodent (Altman and Das, 1965; Kempermann et al., 2003), 12 weeks in the macaque (Gould et al., 2001), and 2 years in the human (Eriksson et al., 1998).”
Neurogenesis in the Adult Hippocampus. (2015, background): “It is, thus, assumed that new oligodendrocytes in the adult dentate gyrus, which are very rare anyway (Kempermann et al. 2003; Steiner et al. 2004), originate from a distinct pool of precursor cells that are characterized by their expression of proteoglycan NG2.”
Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons (2007, background): “The adult-born cells that survive this initial period of cell death differentiate, for the most part into granule neurons, and survive for several months within the DG [8].”
LIF and BMP signaling generate separate and discrete types of GFAP-expressing cells (2005, background): “The glycoprotein LeX (CD15/SSEA1) is also expressed by neural stem/progenitor cells (Capela and Temple, 2002; Kim and Morshead, 2003).”
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis (2011, methodology): “Adult-born granule cells were birthdated with BrdU labeling and injected 16 wk later with shRNA-expressing virus targeting Prox1 mRNA or control lentiviruses, at a time point when newborn granule cells are stably integrated into the hippocampal circuitry and many of them express calbindin (15, 30, 3”