Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons

By David Dupret, Annabelle Fabre, M. Döbrössy, Aude Panatier, Jose Julio Rodriguez, S. Lamarque, V. Lemaire, Stephane Oliet, P. Piazza, D. Abrous. 2007

438 citations recorded by the source corpus.

The role of adult hippocampal neurogenesis in spatial learning remains a matter of debate. Here, we show that spatial learning modifies neurogenesis by inducing a cascade of events that resembles the selective stabilization process characterizing development. Learning promotes survival of relatively mature neurons, apoptosis of more immature cells, and finally, proliferation of neural precursors. These are three interrelated events mediating learning. Thus, blocking apoptosis impairs memory and inhibits learning-induced cell survival and cell proliferation. In conclusion, during learning, similar to the selective stabilization process, neuronal networks are sculpted by a tightly regulated selection and suppression of different populations of newly born neurons.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

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Citations in the corpus

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “For example, learning in the MWM promotes the survival of DGCs that were born 7 days before the onset of MWM training and, at the same time, induces apoptosis in DGCs that were born 3 days befor”
Adult neurogenesis and the plasticity of the dentate gyrus network (2011, background): “Notably, hippocampus-dependent learning paradigms that require NMDA receptor-mediated activity have also been shown to promote the survival of specific populations of adult-born neurons (Gould et al., 1999; Dupret et al., 2007).”
Impaired Adult Neurogenesis Associated with Short-Term Memory Defects in NF-κB p50-Deficient Mice (2008, background): “Recently, Dupret et al. (2007) have proposed that spatial learning requires both addition and removal of the newly generated neurons, providing evidence of an even more complex mechanism contributing to memory formation in mammals.”
Structural Plasticity and Hippocampal Function (2010, background): “Further adding to the complex effects of learning on adult neurogenesis are studies showing that besides affecting cell survival and cell death, learning also influences cell proliferation, depending on the specific phase of the learning process assessed (Döbrössy et al. 2003, Dupret et al. 2007).”
Adult-Generated Hippocampal Neurons Allow the Flexible Use of Spatially Precise Learning Strategies (2009, background): “respect to both learning and affective functions [1–8].”
Mechanisms and functional implications of adult neurogenesis. (2008, neutral): “(Dupret et al., 2007).”
Modification of hippocampal circuitry by adult neurogenesis (2012, background): “An interesting example comes from the study of interaction of spatial learning and hippocampal neurogenesis (Dupret et al., 2007).”
Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats (2010, neutral): “In addition to this, the dentate gyrus exhibits lifelong structural plasticity in the form of adult neurogenesis, a process that has been implicated in hippocampus-dependent learning and memory (Deng et al. 2010; Dupret et al. 2007; Kempermann 2005; Leuner and Gould 2010).”
GABA-CREB signalling regulates maturation and survival of newly generated neurons in the adult hippocampus (2009, background): “…exposure to an enriched environment (van Praag et al., 1999; Tashiro et al., 2007) and hippocampus-dependent learning paradigms (Gould et al., 1999; Dupret et al., 2007; Kee et al., 2007; Aimone et al., 2009), all of which are considered to augment hippocampal network activity (van Praag et al.,…”