Synapse formation on neurons born in the adult hippocampus

By N. Toni, E. Teng, E. Bushong, James Bradley Aimone, Chunmei Zhao, A. Consiglio, H. van Praag, M. Martone, Mark Ellisman, Fred H. Gage. 2007

590 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Such enhanced plasticity may give adultborn neurons an advantage in the competition with mature neurons for selective formation and stabilization of afferent and efferent synaptic connections (Tashiro et al., 2006; Toni et al., 2007).”
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “By approximately day 16, spines begin to appear on the dendrites of adult-born DGCs, forming synapses with the afferent axon fibres in the perforant pathway that come from the entorhinal corte”
Computational influence of adult neurogenesis on memory encoding. (2009, unknown): “, 2006), spine formation (Toni et al., 2007), physiological dynamics (Esposito et al.”
Frontiers in Computational Neuroscience a Model for Cortical Rewiring following Deafferentation and Focal Stroke (2009, unknown): “…sigmoidal function: F X e i N i t i t X i t + + − − = + , ≤ ≤ , + 1 1 1 1 1 1 ( ) θ β with (3) axons can merge to form functioning synapses (Knott et al., 2006; Toni et al., 2007) that, in turn, are stabilized by LTP and weakened by LTD (Engert and Bonhoeffer 1999; Yuste and Bonhoeffer, 2001).”
Neurogenesis in the Adult Hippocampus. (2015, background): “Compatible with this finding, the elaboration of the excitatory input seems to be largely completed 60 days after cell division (Toni et al. 2007).”
Structural Plasticity and Hippocampal Function (2010, background): “This dendritic regression appears to be restricted to the infrapyramidal blade during this life stage (Zehr et al. 2008), perhaps because this part of the GCL is less mature than the suprapyramidal blade.”
Structural Components of Synaptic Plasticity and Memory Consolidation. (2015, background): “Spine shape and number are not necessarily dependable predictors of synapse size, location, or composition (Fiala et al. 1998; Toni et al. 2007; Bock et al. 2011; Shu et al. 2011).”
The effects of exercise and stress on the survival and maturation of adult-generated granule cells (2009, unknown): “The increased survival and more rapid functional maturation observed in runners are particularly important to consider in light of the large number of studies of adult neurogenesis that use running wheels as a standard housing feature (Laplagne et al., 2006; Laplagne et al., 2007; Toni et al., 2008;”
Adult neurogenesis and the olfactory system. (2009, background): “Staining for synapsin, a marker of presynaptic specializations, and electron microscopy show axosomatic (van Praag et al., 2002), axodendritic, and axospinous synapses (Toni et al., 2007).”
Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb (2013, background): “As with the connections from the subiculum and well in agreement with previous morphological and electrophysiological studies (35, 40), labeling of neurons in the EC was observed only at later time points, with 3 wk after neurogenesis being the terminus post quem for a steep increase in synapse form”
Adult hippocampal neurogenesis and its role in Alzheimer's disease (2011, background): “The surviving cells send dendrites to the molecular layer of DG to receive inputs from the EC and send axonal projections to the CA3 subfield of the hippocampus to innervate hilar interneurons, mossy cells and CA3 pyramidal cells (Figure 1), thereby integrating into existing neuronal circuits [18,19”
Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network (2012, unknown): “Glutamatergic synapses begin to form on dendritic spines when young GCs are approximately 16 d old and continue to form for approximately 2 mo (4, 5).”
Adult-born hippocampal neurons are more numerous, faster-maturing and more involved in behavior in rats than in mice (2009, background): “…studies (van Praag et al., 2002; Espósito et al., 2005; Ge et al., 2006; Ge et al., 2007), as well as some morphological (Zhao et al., 2006; Toni et al., 2007) and behavioral (Jessberger and Kempermann, 2003; Kee et al., 2007) experiments, suggest that new neurons are minimally functional…”