Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain.

By Xin Duan, Jay H. Chang, S. Ge, R. Faulkner, Ju Young Kim, Yasuji Kitabatake, Xiao-Bo Liu, Chih-hao Yang, J. Jordan, Dengke K. Ma and 6 more. 2007

671 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

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Citations in the corpus

Mechanisms and functional implications of adult neurogenesis. (2008, positive): “The DISC1 protein controls dendritic growth and physiological maturation in newborn dentate granule cells (Duan et al., 2007).”
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer’s Disease (2009, positive): “In the DG, adultborn granule cells (GCs) may contribute to cognition and mood regulation (Clelland et al., 2009; Duan et al., 2007; Santarelli et al., 2003; Shors et al., 2001).”
Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain (2008, methodology): “We further quantified the development of the adult-born boutons with several morphologic features that have been used in previous studies (16, 17) [see Methods; all morphologic data are summarized in supporting information (SI) Table S1].”
Adult neurogenesis and the olfactory system. (2009, background): “…1 (DISC1), a schizophrenia susceptibility gene, has been implicated in migration, dendritic development, and synaptic integration of new DGCs. Surprisingly, disruption of DISC1 increases dendritic arborization and speeds maturation and synaptic integration (Duan et al., 2007).”
Adult neurogenesis and the plasticity of the dentate gyrus network (2011, background): “Ectopic migration towards the molecular layer occurring in DISC1 loss of function (Duan et al., 2007) or toward the hilus after epileptic seizures (Scharfman et al., 2003; Jessberger et al., 2007; Kron et al., 2010) indicates that newborn DGCs do have the potential to migrate further away from the…”
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 (2009, positive): “Specific shRNAs against mouse disc1 (DISC1-shRNA) (Duan et al., 2007) and mouse pten (PTEN-shRNA) (Jaworski et al.”
Synaptic integration and plasticity of new neurons in the adult hippocampus (2008, background): “Furthermore, genetic manipulation of adult neural stem cells and their local environment, or ‘neurogenic niche’, is starting to reveal key molecular mechanisms underlying adult neurogenesis and activity-dependent regulation (Ge et al. 2006; Tashiro et al. 2006; Duan et al. 2007).”
DISC1 regulates neural progenitor proliferation via modulation of GSK3β/β-catenin signaling (2009, positive): “Consistent with a previous report (Duan et al., 2007), we also observed aberrant positioning and increased complexity of dendritic morphology in DISC1 knockdown granule neurons (data not shown).”
GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knock-in Mice (2009, methodology): “Adult neurogenesis is regulated by several factors, including transcription factors, hormones, neurotransmitters, cell niches, exercise, and specific molecules (Alvarez-Buylla and Lim, 2004; Lie et al., 2004; Ming and Song, 2005; Duan et al., 2007; Zhao et al., 2008; Suh et al., 2009), although the ”
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. (2016, positive): “Ablation of DISC1, one of the best-characterized susceptibility genes, results in reduced levels of hippocampal neurogenesis, altered morphogenesis, and granule cell positioning, as well as impaired hippocampus-dependent behavior in rodents (Duan et al., 2007; Kvajo et al., 2008).”
Directed differentiation of hippocampal stem/progenitor cells in the adult brain (2008, background): “In contrast with newborn granule cells, which stay in the inner parts of the granule cell laye”
Modification of hippocampal circuitry by adult neurogenesis (2012, background): “For example, knockdown of Disrupted-in-Schizophrenia 1 (DISC1) in newborn granule cells leads to overextended migration to the molecular layer (Duan et al., 2007).”
Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases (2013, background): “Their study revealed DISC1 to be a key regulator in maintaining the pace of maturation and integration of adult-born neurons (Duan et al., 2007).”