Computational influence of adult neurogenesis on memory encoding.

By James Bradley Aimone, Janet Wiles, Fred H. Gage. 2009

409 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience, Computational Biology & Bioinformatics, Neuroscience

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Citations in the corpus

On the role of neurogenesis in overcoming catastrophic forgetting (2018, background): “Finally, additional theories suggest that one function of neurogenesis in the mammalian hippocampus is the encoding of time for the formation of temporal associations in memory [17].”
Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain (2009, background): “A computational study in our lab suggests that immature DGCs may serve as pattern integrators to build artificial links among different events experienced during episodic memory formation (Aimone et al., 2009).”
Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. (2016, positive): “These include encoding of temporal information into memories (Aimone et al., 2006; Becker and Wojtowicz, 2007), avoidance of memory interference and cognitive flexibility during learning of new tasks (Chambers et al., 2004), and balancing pattern separation/integration (Aimone et al., 2009).”
Adult-Generated Hippocampal Neurons Allow the Flexible Use of Spatially Precise Learning Strategies (2009, background): “A very detailed model of adult neurogenesis emphasizes the potential role of new neurons in the encoding of temporal information (‘‘time-stamp model’’) [30,31].”
Structural Plasticity and Hippocampal Function (2010, background): “In fact, computational (Aimone et al. 2009) and experimental (Clelland et al. 2009) work suggests that immature neurons may be critical for creating associations between memories learned close in time (Aimone et al. 2009) and may aid in distinguishing memories closely related in space (Clelland et…”
Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation (2011, background): “increase correlations across the GCs’ responses to inputs (Aimone et al., 2009; Weisz and Argibay, 2009).”
GABA-CREB signalling regulates maturation and survival of newly generated neurons in the adult hippocampus (2009, background): “…receptor activation appears to provide a mechanism through which hippocampal network activity could regulate neurogenesis to recruit the precise number of new neurons for activity-dependent modification of the hippocampal circuitry (Tashiro et al., 2006b; Ge et al., 2007; Aimone et al., 2009).”
Hippocampal granule cells opt for early retirement (2010, background): “The excitable population might participate in setting up CA3 representations and then become quiescent for future events, even ones resembling old memories [‘‘temporal tagging’’; (Aimone et al., 2006, 2009)].”
Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus (2010, background): “VC 2010 WILEY PERIODICALS, INC. neurons makes them a preferential substrate for new memories or representations (Doetsch and Hen, 2005; Aimone et al., 2006, 2009; Kee et al., 2007; Tashiro et al., 2007).”