Hippocampal granule cells opt for early retirement

By C. B. Alme, R. A. Buzzetti, D. Marrone, J. Leutgeb, Monica K. Chawla, M. Schaner, J. Bohanick, T. Khoboko, Stefan Leutgeb, Edvard I. Moser and 3 more. 2010

182 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

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Citations in the corpus

Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “Several studies additionally reported that putative granule cells often had multiple place fields (Jung and McNaughton, 1993; Leutgeb et al., 2007; Alme et al., 2010; Park et al., 2011), further confounding the concept of sparse granule cell coding.”
Spatial representations of granule cells and mossy cells of the dentate gyrus (2017, background): “These data contradicted the predictions from the classic DG models that granule cells employed a very sparse coding scheme and multiple lines of evidence for sparse granule cell activity that have more recently emerged (Alme et al., 2010; Danielson et al., 2016; Chawla et al., 2005; Neunuebel and Kn”
CA3 Retrieves Coherent Representations from Degraded Input: Direct Evidence for CA3 Pattern Completion and Dentate Gyrus Pattern Separation (2014, background): “, 2007), and these cells may dominate the responses of the DG (Alme et al., 2010; Neunuebel and Knierim, 2012).”
Modeling new neuron function: a history of using computational neuroscience to study adult neurogenesis (2011, background): “synaptic loop, the function of the DG is increasingly being called into question (Leutgeb & Moser, 2007; Treves et al., 2008; Aimone et al., 2010b; Alme et al., 2010).”
Functional Imaging of Dentate Granule Cells in the Adult Mouse Hippocampus (2016, unknown): “…very low spiking activity of adult granule cells, in agreement with previous reports that showed relative sparseness of DG activity using in vivo electrophysiological recordings and during in vivo imaging (Jung and McNaughton, 1993; Leutgeb et al., 2007; Alme et al., 2010; Danielson et al., 2016).”
Spatial firing correlates of physiologically distinct cell types of the rat dentate gyrus (2012, background): “Thus, the present demonstration that single- and multiple-field cells constitute distinct cell types advances our understanding of the variety of firing patterns of DG neurons and raises the questions of what cell type corresponds to mature granule cells versus the multiplicity of other cell types i”
Sparse activity of identified dentate granule cells during spatial exploration (2016, background): “Although several structure–function schemes have been proposed (Leutgeb et al., 2007; Alme et al., 2010; Lisman, 2011; Neunuebel and Knierim, 2014), the cellular identity of active and silent neurons has remained largely unexplored.”
In contrast to many other mammals, cetaceans have relatively small hippocampi that appear to lack adult neurogenesis (2013, background): “The hippocampus and associated cortices are neural structures thought to be fundamentally involved in the learning and retention of facts, events and space in time (Alme et al. 2010; Buzsáki and Moser 2013).”
Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network (2012, unknown): “1 A–D), likely contributes greatly to observation that GCs are notoriously silent in vivo (23, 24), and may help explain why mature GCs appear to “retire” from the DG under certain circumstances (25).”
Theta-Gamma-Modulated Synaptic Currents in Hippocampal Granule Cells In Vivo Define a Mechanism for Network Oscillations (2014, result): “In contrast, more recent work indicated that GCs in vivo are largely silent (Alme et al., 2010).”