Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells

By R. Zaidel-Bar, C. Ballestrem, Zvi Kam, Benjamin Geiger. Journal of Cell Science, 2003

717 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/9b4656c5b21f8351d17b9cdd3dc094aa2e870d44

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Citations in the corpus

Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner (2008, neutral): “These studies were facilitated by the identification of small adhesions near the leading edge of motile cell”
Environmental sensing through focal adhesions (2009, background): “As a rule, the formation of the focal complexes occurs underneath the lamellipodia”
Analysis of the myosinII-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation (2011, background): “This is followed by formin-mediated elongation of an actin/α-actinin bundle, where adapter proteins zyxin and tensin accumulat”
Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration. (2006, background): “FA proteins constantly exchange with the cytoplasmic or membrane-associated pool (Zaidel-Bar et al., 2003; Zimerman et al., 2004).”
Focal adhesion regulation of cell behavior. (2004, background): “Initial foci of adhesion form just posterior to the actin network, and grow into focal complexes abundant in tyrosine phosphorylation, and containing integrin, talin, paxillin, vinculin and FAK [86,119].”
Physics of adherent cells (2013, methodology): “Other forces, such as hydrodynamic flow (Zaidel-Bar et al., 2003) or stretching forces applied to the substrate (Kaunas et al.”
Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration (2010, background): “In addition, some studies show compositional differences between small and large FAs (Laukaitis et al. 2001; Zaidel-Bar et al. 2003, 2007a; Zimerman et al. 2004), although the order of protein addition and the requirement for myosin II activity and/or tension in FA recruitment is not known.”
Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis (2011, neutral): “In contrast, we found that incubation with serum from subjects with recurrent FSGS (high in suPAR) or with recombinant suPAR strongly induces the AP5 signal in a pattern highlighting areas of focal adhesions; these adhesions are known to be the location of β 3 integri”
PKD1/PKCμ promotes αvβ3 integrin recycling and delivery to nascent focal adhesions (2004, methodology): “Work by Zaidel-Bar et al (2003) has shown that proteins”
Integrins and extracellular matrix in mechanotransduction. (2010, background): “Its localization to focal adhesions requires high contractility, indeed, it is one of the few proteins that localize strongly to focal adhesions but poorly to focal complexes (Zaidel-Bar et al. 2003).”
Regulation of actin assembly associated with protrusion and adhesion in cell migration. (2008, background): “Vinculin, -actinin, VASP, and FAK appear in late focal complexes (111, 190, 260, 261) (Fig.”
Focal adhesion kinase: in command and control of cell motility (2005, background): “Although FAK recruitment to focal contacts is associated with increased FAK tyrosine phosphorylatio”
Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands. (2007, background): “Zaidel-Bar et al. ( 45 ) showed that zyxin is incorporated to adhesion sites upon local retraction, suggesting that this process is force dependent.”