Integrins and extracellular matrix in mechanotransduction.

By M. Schwartz. Cold Spring Harbor Perspectives in Biology, 2010

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The extracellular matrix modulates the hallmarks of cancer (2014, positive): “This stiffened ECM associates with tumor aggression and correlates with an increased propensity toward metastasis and poorer patient outcome [6,30].”
A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. (2013, positive): “…are cell shape, cell geometry, deformation generated by the pulling forces of the extracellular matrix (ECM) and of neighboring cells, and the associated changes in cytoskeletal organization and tension (Berrier and Yamada, 2007; Miranti and Brugge, 2002; Schwartz, 2010; Vogel and Sheetz, 2006).”
Role of YAP/TAZ in mechanotransduction (2011, background): “3e); (3) endogenous target gene expression in cells plated on soft hydrogels (Fig.”
The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices (2011, methodology): “In brief, frozen tissues (150–200 mg) or tumors (200–j400 mg) were homogenized and extracted sequentially to remove (1) cytosolic proteins (2), nuclear proteins (3), membrane proteins (4), and cytoskeletal proteins leaving a final insoluble fraction enriched for ECM proteins.”