Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands.

By E. A. Cavalcanti‐Adam, T. Volberg, A. Micoulet, Horst Kessler, Benjamin Geiger, Joachim Pius Spatz. Biophysical Journal, 2007

893 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/d73530fc695482bc7254ca8dc54a663a48575b3b

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Citations in the corpus

Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells (2009, background): “observe that the spacing between integrin clusters regulates cell spreading in fibroblasts [27].”
Integrin-mediated mechanotransduction (2016, background): “The first adhesion structure assembles at the leading edge of cell protrusions by nucleating three to six integrins interspaced by less than 70 nm into short-lived nascent adhesions (NAs; Fig. 1; Cavalcanti-Adam et al., 2007; Hu et al., 2007; Bachir et al., 2014).”
Demineralization–remineralization dynamics in teeth and bone (2016, neutral): “225,226 Controlling the surface topography at nanoscale level or chemistry of scaffolds or implants could influence cells spreading 222 and differentiation.”
The myofibroblast: paradigm for a mechanically active cell. (2010, background): “Indeed, experiments show that the transition of focal complexes into stress fiber-associated FAs requires lateral integrin spacing of under 70 nm (Arnold et al., 2004; Cavalcanti-Adam et al., 2007) and depends on a critical density of extracellular ligands (Koo et al., 2002).”
Balancing forces: architectural control of mechanotransduction (2011, positive): “As shown through the use of functionalized gold dots on nanopatterned surfaces, differences in average ligand spacing of as little as ∼10 nm seem to be capable of dictating whether integrins are able to assemble into focal adhesion”
Environmental sensing through focal adhesions (2009, background): “Although the cells spread, multiplied and displayed restrained migratory behaviour on surfaces that have nanogold spacings of 73 n”