Environmental sensing through focal adhesions

By Benjamin Geiger, Joachim Pius Spatz, A. Bershadsky. Nature reviews. Molecular cell biology, 2009

2,521 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/2e1c547a2e7f8683923c84420d4a94f7cf9f5533

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Citations in the corpus

Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells (2009, background): “internally by the intracellular contractile actin–myosin-II machinery, or applied externally [10].”
Graphene substrates promote adherence of human osteoblasts and mesenchymal stromal cells (2010, neutral): “strates with different topography and rigidity [18]).”
Integrins in cell migration. (2011, neutral): “1) (Geiger et al. 2009; Geiger and Yamada 2011).”
Integrins (2009, background): “For a majority of integrins, the linkage is to the actin cytoskeleton (Geiger et al. 2009), whereas α6β4 connects to the intermediate filament system (Nievers et al. 1999).”
Integrin Structure and Function (2010, background): “Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase signaling protein that most likely interacts indirectly with b integrins through its association with paxillin (Geiger et al. 2009; Brakebusch and Fassler 2003).”
The final steps of integrin activation: the end game (2010, background): “These intracellular structures include focal complexes and focal adhesions”
Balancing forces: architectural control of mechanotransduction (2011, neutral): “Among the most-studied mechano-sensory complexes are focal adhesions (reviewed in Ref”
Actin stress fibers – assembly, dynamics and biological roles (2012, background): “Focal adhesions are often connected to actin stress fibers, which thus appear to play an important role in cell adhesion and migration (Geiger et al., 2009; Parsons et al., 2010).”
Titanium Surface Characteristics, Including Topography and Wettability, Alter Macrophage Activation (2015, background): “The configuration of the cells may alter the factors produced [29].”
The integrin adhesome: from genes and proteins to human disease (2014, neutral): “All rights reserved Nature Reviews | Molecular Cell Biology GAPs (14)a PtdIns phosphatases (3) Actin regulators (17) Adaptors (73) Adhesion receptors (42) Lipid GTPases (6) Ser/Thr phosphatases (4) PtdIns kinases (2) GEFs (16) Tyr kinases (11) Ser/Thr kinases (11) E3 ligases (3) Proteases (4) Channe”
Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration (2010, background): “Many of these strengthening processes are accelerated by the application of mechanical force and are crucial for the ability of cells to sense and respond to internal or external mechanical forces (Bershadsky et al. 2003, Geiger et al. 2009).”
The physics of cancer: the role of physical interactions and mechanical forces in metastasis (2011, neutral): “Focal adhesions formed on 2D substrates are typically 1–10 μm in size, much larger than the fibre diameter of the EC”