Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration

By Margaret L. Gardel, I. Schneider, Yvonne Aratyn-Schaus, Clare M. Waterman. Annual Review of Cell and Developmental Biology, 2010

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Directed cell migration is a physical process that requires dramatic changes in cell shape and adhesion to the extracellular matrix. For efficient movement, these processes must be spatiotemporally coordinated. To a large degree, the morphological changes and physical forces that occur during migration are generated by a dynamic filamentous actin (F-actin) cytoskeleton. Adhesion is regulated by dynamic assemblies of structural and signaling proteins that couple the F-actin cytoskeleton to the extracellular matrix. Here, we review current knowledge of the dynamic organization of the F-actin cytoskeleton in cell migration and the regulation of focal adhesion assembly and disassembly with an emphasis on how mechanical and biochemical signaling between these two systems regulate the coordination of physical processes in cell migration.

Subfields: Atomic and Molecular Physics, and Optics, Cell Biology, Ecology, Evolution, Behavior and Systematics

View Paper: https://www.semanticscholar.org/paper/f2fb9a5082d6e2e799ad7b48aa51871acc39ec51

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In Cell Biology

1. D. Schlaepfer
2. D. Calderwood

Citations in the corpus

• FAK promotes recruitment of talin to nascent adhesions to control cell motility (2012, background): “In spreading cells, edge protrusions are connected to the underlying extracellular matrix via integrin and cytoskeletal structures, termed nascent adhesions, that form concurrently with lamellipodia protrusion (Gardel et al., 2010).”