Focal adhesion regulation of cell behavior.

By Michele A. Wozniak, K. Modzelewska, Lina Kwong, P. Keely. Biochimica et Biophysica Acta, 2004

1,058 citations recorded by the source corpus.

Focal adhesions lie at the convergence of integrin adhesion, signaling and the actin cytoskeleton. Cells modify focal adhesions in response to changes in the molecular composition, two-dimensional (2D) vs. three-dimensional (3D) structure, and physical forces present in their extracellular matrix environment. We consider here how cells use focal adhesions to regulate signaling complexes and integrin function. Furthermore, we examine how this regulation controls complex cellular behaviors in response to matrices of diverse physical and biochemical properties. One event regulated by the physical structure of the ECM is phosphorylation of focal adhesion kinase (FAK) at Y397, which couples FAK to several signaling pathways that regulate cell proliferation, survival, migration, and invasion.

Subfields: Cell Biology, Immunology and Allergy, Oncology

View Paper: https://www.semanticscholar.org/paper/be973a9c41ca03e104e975259339245fbf3c83f0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Brendon M. Baker
2. Christopher S. Chen
3. C. Waterman-Storer
4. Kenneth M. Yamada
5. J. Esko
6. A. Berrier
7. S. Gupton

In Immunology and Allergy

1. Christopher S. Chen
2. Brendon M. Baker
3. C. Waterman-Storer
4. Kenneth M. Yamada
5. A. Berrier
6. S. Gupton

In Oncology

1. Kenneth M. Yamada

Citations in the corpus

• General functionalization route for cell adhesion on non-wetting surfaces. (2010, background): “Surface properties regulate a variety of intracellular signal cascades for cell proliferation, migration, differentiation, and apoptosis [5,6].”
• Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues (2012, background): “…number of adhesions are among the better understood signals that are integrated by the cell in order to regulate many fundamental cellular behaviors, including survival, differentiation, proliferation and migration (Wozniak et al., 2004; Weber et al., 2011; Orr et al., 2006; Geiger et al., 2009).”
• Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration. (2006, background): “FAs contain transmembrane integrins that link the ECM to F-actin via structural and signaling proteins (Critchley et al., 1999; Wozniak et al., 2004).”
• Scaffolds and cells for tissue regeneration: different scaffold pore sizes—different cell effects (2016, background): “Cell proliferation, differentiation and migration are mainly cell-anchorage-dependent processes that inhibit cell apoptosis and activate cytoskeleton reorganization (Wozniak et al. 2004).”
• Cell–matrix adhesion (2007, background): “Similarly, increasing the understanding of the roles of local tension and feedbackmechanismsmay lead to the development of approaches to facilitate wound repair and prevent scarring and fibrosis (Xiao et al., 2004; Metcalfe and Ferguson, 2007).”
• The sweet and sour of cancer: glycans as novel therapeutic targets (2005, background): “Focal adhesions are supramolecular complexes that link integrin-mediated ECM adhesion to the cytoskeleton as well as initiate signalling pathways that affect cell migration, mechanosensing, and proliferation during cell motilit”