Interleukin-10 and the interleukin-10 receptor.

By K. Moore, R. de Waal Malefyt, R. Coffman, A. O’Garra. Annual Review of Immunology, 2001

7,139 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9ad57711f9e354718a58064f2644389e97e716c7

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IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex (2003, background): “Nevertheless, it is clear that they play a role in the induction and regulation of the immune and inflammatory response”
A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses (2008, background): “During the resolution of inflammation, a decrease in or lack of IL-1β may simultaneously decrease the production of IL-17 and enhance the production of IL-10, which would further favor immune contraction through its anti-inflammatory propertie”
In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines (2002, background): “610 In Vitro Generation of Regulatory CD4 T Cells strate for the first time that IL-10 is a positive autocrine factor that acts directly on the T cell in the absence of APCs to enhance the development of IL-10–producing T cells, which is in contrast to its negative feedback role in the development o”
Regulatory T cells: friend or foe in immunity to infection? (2004, neutral): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=16161,16162">IL-12R”
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10 (2007, background): “It is now recognized that IL-10 can be produced by a range of adaptive and innate immune cell”
Anti- and Pro-inflammatory Roles of TGF-β, IL-10, and IL-22 In Immunity and Autoimmunity (2009, background): “Unlike when TGF-b signaling is blocked in T cells, blockade of TGF-b signaling in natural killer (NK) and dendritic cells (DCs) does not cause spontaneous disease.”
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses (2007, background): “IL-10 is a pleiotrophic cytokine capable of suppressing proinflammatory cytokine production by APCs and other cells and of limiting T H 1 differentiatio”
Into the Eye of the Cytokine Storm (2012, background): “The production of anti-inflammatory cytokines, mainly IL-10 by macrophages and certain types of T cells (Th2 and regulatory T cells) and B cells (105), represents another mechanism involved in regulating proinflammatory responses.”
Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10 (2009, background): “IL-10 has been recognized as a major anti-inflammatory cytokine serving as a negative regulator of the response of both innate and adaptive immune cells, particularly during persistent bacterial and parasitic infections, where it suppresses pathogen clearance, infection-associated immunopathology or”
Cellular and molecular mechanisms of fibrosis (2008, background): “IL-10 functions as a general immunosuppressive cytokine, which down-regulates chronic inflammatory responses through many mechanisms [149].”
TH1 cells control themselves by producing interleukin-10 (2007, background): “jpg" NDATA ITEM> ]> Interleukin-10 ( IL-10 ) is a cytokine with broad anti-inflammatory properties that result from its ability to inhibit the function of both macrophages and dendritic cells (DCs), including their production of pro-inflammatory cytokine”
The germless theory of allergic disease: revisiting the hygiene hypothesis (2001, background): “cgi?l=3557">IL-1 receptor antagonist ; inhibition of dendritic cell differentiation; suppression of inflammatory chemokine production; inhibition of matrix metalloproteinase production; downregulation of leukocyte adhesion molecule expression; suppression of T-cell proliferation; inhibition of T H 1”