Into the Eye of the Cytokine Storm

By J. Tisoncik, M. J. Korth, C. Simmons, J. Farrar, T. Martin, Michael G. Katze. Microbiology and Molecular Reviews, 2012

1,751 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/435bd4bfc43c8e55b14aac55445390f0f726da0a

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Citations in the corpus

Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19 (2020, background): “However, numerous viral and non-viral infections do give rise to cytokine storm, acute respiratory distress, and lymphopenia (Tisoncik et al., 2012).”
Assessing nitrogen dioxide (NO2) levels as a contributing factor to coronavirus (COVID-19) fatality (2020, positive): “This syndrome, also known as hypercytokinemia is an uncontrolled release of proinflammatory cytokines (Tisoncik et al., 2012) and it is a severe reaction of the immune system, leading to a chain of destructive processes in the body that can end in death.”
Cytokine release syndrome (2018, background): “Cytokine storm due to massive T cell stimulation is also a proposed pathomechanism of severe viral infections such as influenza [15, 16].”
Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients (2020, background): “It has been reported that following SARS-CoV infection, dysregulated cytokine/chemokine responses and higher virus titers cause an inflammatory cytokine storm with lung immunopathological injury 12, 14 .”
Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies (2020, background): “It has been reported that chimeric antigen receptor (CAR)-T-cell therapy could help to distinguish CRS from a cytokine storm (2).”
The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease (2020, background): “Furthermore, a MAS/sHLH has been described in the related SARS coronavirus sufferers in prior studies [26,27].”
Cytokines in Inflammatory Disease (2019, background): “Therefore, in the past when the term “cytokine storm” arose, it explained inflammation as a sudden release of cytokines to upregulate an inflammatory process [18].”
The cytokine storm of severe influenza and development of immunomodulatory therapy (2015, background): “7 The inflammatory response begins when the pathogen-associated molecular pattern (PAMP) from the virus is recognized by the pattern recognition receptors (PRRs) of innate immune cells.”
Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance (2017, positive): “The type of hyperactivation and cytokine response seen in LabR and Lab is consistent with descriptions of cytokine storms associated with a lethal IAV infection (Kash et al., 2006; Kobasa et al., 2007; Tisoncik et al., 2012).”
PathVisio 3: An Extendable Pathway Analysis Toolbox (2015, neutral): “The visualization options in PathVisio 3 can be used to visualize time-series data (one column for each time point) [2], tissue expression comparisons (one column for each tissue) [21] and other complex multi-omics experiments.”
COVID-19: what has been learned and to be learned about the novel coronavirus disease (2020, background): “These cytokines induce immune cells to release a vast number of free radicals which are the major cause of ARDS and multiple organ failure [67] .”
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes (2020, positive): “Acute respiratory distress syndrome (ARDS) and systemic inflammatory response syndrome (SIRS) are other serious consequences of this cytokine storm (Ragab et al., 2020; Tisoncik et al., 2012).”