A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

By E. Volpe, N. Servant, Raphaël Zollinger, S. Bogiatzi, P. Hupé, E. Barillot, V. Soumelis. Nature Immunology, 2008

1,052 citations recorded by the source corpus.

Subfields: Immunology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/0b35ed2c405de1b9d2a4d4d0cb83fd6b6cbc999f

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In Immunology

1. K. Mills
2. A. Di Cesare
3. P. Barnes
4. D. Sheppard
5. G. Lee
6. Frank O. Nestle
7. M. Travis
8. P. Di Meglio

In Pathology and Forensic Medicine

1. D. Sheppard
2. C. A. Dinarello

Citations in the corpus

• Th17 cells in human disease (2008, background): “who found that TGF-b, IL-7b and IL-6 induced Th17 differentiation in naı̈ve human T cells from peripheral blood (24).”
• Human inflammatory dendritic cells induce Th17 cell differentiation. (2013, methodology): “In humans, IL-6, IL1-b, TGFb, and IL-23 have been proposed to induce the development of Th17 cells (Acosta-Rodriguez et al., 2007; Manel et al., 2008; Volpe et al., 2008; Wilson et al., 2007).”
• TGF-β Activation and Function in Immunity (2013, background): “However, follow-up studies have shown that the role for TGF-β in Th17 cell differentiation is conserved between mice and humans (98, 99), although in some contexts Th17 cell differentiation does appear to occur in the absence of TGF-β (100).”
• The cytokine network in asthma and chronic obstructive pulmonary disease. (2008, background): “IL-6, IL-1β, TGF-β, and IL-23 are all involved in the differentiation of human Th17 cells (39, 40).”
• The Balance of Th17 versus Treg Cells in Autoimmunity (2018, background): “The effect of IL-6 is bolstered by other proinflammatory cytokines, including IL-1β, IL-21, IL-23, and TNF-α [3,53,58].”
• The IL-23/Th17 axis in the immunopathogenesis of psoriasis. (2009, background): “In addition to IL-17A, Th17 cells have been collectively shown to also produce IL-17F, IL-22, and IL-26, as well as IL-6, IL-21, TNF-a, and IFN-g (Chen et al., 2007; Wilson et al., 2007; Acosta-Rodriguez et al., 2007a; Manel et al., 2008; Volpe et al., 2008).”