Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses

By T. Denning, Yi‐chong Wang, S. Patel, I. Williams, Bali Pulendran. Nature Immunology, 2007

1,038 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/41d435106e399bb74e51e10ac363a2522c2e01f8

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Citations in the corpus

• Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. (2012, background): “, 2001) and are believed to contribute to gut homeostasis by production of IL-10 (Denning et al., 2007; Hadis et al., 2011).”
• Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis (2009, result): “Our findings are in agreement with the results of a study showing that IL-10 from lamina propria macrophages is important for the induction of Foxp3 expressio”
• IL-6 and STAT3 are required for survival of intestinal epithelial cells and development of colitis associated cancer (2009, methodology): “Another report has suggested that intestinal dendritic cells are responsible for IL-6 production triggered by proinflammatory stimuli ( Denning et al., 2007 ).”
• Tumor-associated macrophages: from mechanisms to therapy (2014, background): “TAMs have been found to express IL-10 and TGF-b in different pathological scenarios including human and mouse cancers (Pollard, 2004).”
• Mechanisms of Disease: Inflammatory Bowel Diseases. (2019, background): “Furthermore, they also have the capacity of producing anti-inflammatory cytokines that promote regulatory T-cell differentiation and restrain Th1 and Th17 responses (80).”
• Intestinal lamina propria dendritic cell subsets have different origin and functions. (2009, methodology): “Analysis of Recipient Mice and Flow Cytometry Small intestinal and colonic lamina propria cells were isolated with a technique previously described (Denning et al., 2007).”
• The Microbiome in Infectious Disease and Inflammation (2012, neutral): “In addition to CD103+ DCs, CD11bhighCD11c− LP macrophages preferentially promote iTreg and Tr1 cell differentiation (240).”
• Anti- and Pro-inflammatory Roles of TGF-β, IL-10, and IL-22 In Immunity and Autoimmunity (2009, background): “Recent findings show that macrophages in the lamina propria preferentially induce IL-10 producing cells while DCs promote the generation of Th17 cells [34].”
• Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine (2016, background): “We first analyzed the number of CD11b1CD11c1 cells (which have been reported to induce Th17 cells and produce high levels of IL-6 compared with other innate immune subsets of cells) in the large intestine of RASKG and HC-SKG mice (25,27) (Supplementary Figures 11A and B).”
• Vitamin effects on the immune system: vitamins A and D take centre stage (2008, background): “Notably, one recent study indicated that macrophages and not DCs are responsible for inducing T Reg cells in the intestinal lamina propri”
• Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. (2011, background): “CD11c+MHCII+CD103+ DCs and F4/80+CD11b+ macrophages were present at similar numbers in CX3CR1-deficient and wild-type mice when analyzed by flow cytometry and immunofluorescence microscopy (Figure 5A and data not shown) and expressed similar levels of costimulatory molecules CD40, CD80, and CD86 as ”
• Immunological mechanisms of vaccination (2011, background): “, and various subsets of DCs and macrophages may regulate the differentiation of antigen-specific T cells and B cells at mucosal site”
• 1,25-dihydroxyvitamin D3 and interleukin-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3 (2009, result): “Taken together with the fact that we see no preferential expansion of T cells or increased death in our cultures, these observations are consistent with an effect of 1,25(OH)2D3 on T cell differentiation possibly similar to that of vitamin A (16, 18).”