The germless theory of allergic disease: revisiting the hygiene hypothesis
By M. Wills-Karp, Joanna Santeliz, C. Karp. Nature reviews. Immunology, 2001
863 citations recorded by the source corpus.
Subfields: Dermatology, Immunology and Allergy, Physiology
View Paper: https://www.semanticscholar.org/paper/b5ea97587975e1e9206b58d725dda262b34dddd2
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Citations in the corpus
- Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells (2010, background): “Given these tight associations, it is not surprising that gut microbiota have been linked to pathologies of the immune system, notably allergies and autoimmune disorders (Strachan, 1989; Wills-Karp et al., 2001; Kelly et al., 2007).”
- Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota (2012, background): “The revised hygiene hypothesis proposes that exposure to immunomodulatory gut commensals can provide protection from autoimmune diseases (Wills-Karp et al., 2001).”
- The Impact of the Gut Microbiota on Human Health: An Integrative View (2012, neutral): “A potential mechanism that has been proposed to support the hygiene hypothesis is the counter-regulatory role of interleukin-10 (IL-10) (Wills-Karp et al., 2001).”
- Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances (2016, background): “Alterations of the gut microbiota disrupt this balance, resulting in the deregulation of immune responses that can promote a variety of disease outcomes (Wills-Karp et al., 2001; Yazdanbakhsh et al., 2002; Rautava et al., 2004; Rook and Brunet, 2005; Penders et al., 2007b; Shen et al., 2014).”
- Environmental biodiversity, human microbiota, and allergy are interrelated (2012, background): “Building on the hygiene hypothesis (5, 6), the notion that growing up in a farming environment protects children from allergic sensitization (7, 8), and the emerging understanding of the role of microbes in the development and maintenance of epithelial cell integrity and tolerance (3, 9), the “biodi”
- Suppression of allergic airway inflammation by helminth-induced regulatory T cells (2005, neutral): “Current theories postulate that pathogen-induced T reg cells control both Th1 and Th2 effector populations (2, 3, 11, 16, 27, 53).”
- The rise of childhood type 1 diabetes in the 20th century. (2002, background): “Although this concept may prove unduly simplistic, lack of early stimulation could give rise to a failure of early immune regulation that might, according to genetic susceptibility, permit patterns of response predisposing to autoimmunity or allergy to develop at opposite ends of the Th1/Th2 spectru”