Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10
By Craig L. Maynard, L. Harrington, K. Janowski, J. Oliver, C. Zindl, Alexander Y. Rudensky, C. Weaver. Nature Immunology, 2007
641 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/855ea5d34edaf919f264cd2951c3d242ff306265
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In Immunology
- Shimon Sakaguchi
- Alexander Y. Rudensky
- E. Shevach
- A. O’Garra
- K. Wing
- R. Flavell
- T. Nomura
- Tomoyuki Yamaguchi
Citations in the corpus
- Late Developmental Plasticity in the T Helper 17 Lineage (2009, neutral): “1 reporter mice were isolated as above, with Dynal Beads, and the recovered CD4+ T cells were stained with APC-conjugated anti-CD4 (RM4-5) and FITC-conjugated anti-CD45RB (16A) (BD Biosciences) sorted into CD4+CD45RB+ and CD4+CD45RB fractions as previously described (Maynard et al., 2007).”
- The immune response in tuberculosis. (2013, positive): “tuberculosis infection using 10BiT reporter mice (315).”
- Regulatory T cells exert checks and balances on self tolerance and autoimmunity (2010, background): “For example, IL-10–producing Foxp3 + T reg cells are rare in the spleen but abundant in the lamina propria of the intestine, which supports the observation that T reg cell–specific IL-10 deficiency causes immunopathology in the mucosal surface of the intestine and the lun”
- Mechanisms of foxp3+ T regulatory cell-mediated suppression. (2009, background): “TGF-b may also play a role in the development of Treg cells that are capable of producing IL-10, as shown by the fact that treatment of mice with anti-TGF-b prevented the conversion of CD4+Foxp3 T cells to CD4+Foxp3+IL-10 producers in intestine-associated lymphoid tissues (Maynard et al., 2007).”
- Th17 cells express interleukin-10 receptor and are controlled by Foxp3− and Foxp3+ regulatory CD4+ T cells in an interleukin-10 dependent manner (2011, result): “By contrast, the frequency of IL-10-producing T cells was not different between WT and Cd4-DNIL-10R mice, indicating that IL-10 signaling inTcells isdispensable for theemergenceof thesecells, which is in line with a previous study (Maynard et al., 2007).”
- Regulatory T cells and immune tolerance. (2008, background): “Tregs coexpressing Foxp3 and IL-10 at a single-cell level are indeed found in lamina propria of the intestine but not in the spleen (Uhlig et al., 2006; Maynard et al., 2007).”