IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex
By S. Kotenko, G. Gallagher, V. Baurin, A. Lewis-Antes, Meiling Shen, Nital K. Shah, J. Langer, F. Sheikh, H. Dickensheets, R. Donnelly. Nature Immunology, 2003
1,197 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/f4c234070e94ef76e429238bcbbedfc8ba506cab
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In Immunology
Citations in the corpus
- Interferons, interferon‐like cytokines, and their receptors (2004, background): “IFN-gR1 IFN-gR (220), IFN-gRa (221) 6q23þ2 (C) IFN-g IFN-gR2 AF-1 (90), IFN-gRb (91) 21q22þ11 (T) IFN-g IFN-aR1 IFN-aR (66) 21q22þ11 (T) IFN-a, IFN-b, IFN-o, IFN-d, IFN-e, IFN-k, IFN-l, limitin IFN-aR2 IFN-a/bR (222), IFN-aR2a (65), IFN-aR2b, 21q22þ11 (T) IFN-a, IFN-b, IFN-aR2c, IFN-aR2L (69), IFN-o”
- Zika virus targets human STAT2 to inhibit type I interferon signaling (2016, background): “Type III IFN utilizes different cell-surface receptors than type I IFN, but utilizes the same JAK-STAT machinery, including STAT2 (Kotenko et al., 2003; Sheppard et al., 2003).”
- IFN Regulatory Factor Family Members Differentially Regulate the Expression of Type III IFN (IFN-λ) Genes1 (2007, background): “Quite recently a new class of antiviral cytokines, type III IFNs (IFN- 1–3 or IL-28/29), which are genetically and structurally different from type I IFNs, were identified (1, 2).”
- Lambda Interferon (IFN-λ), a Type III IFN, Is Induced by Viruses and IFNs and Displays Potent Antiviral Activity against Select Virus Infections In Vivo (2006, background): “As already reported by others, IFN- exerts antiviral activity against the ssRNA virus EMCV as well as other RNA viruses (20, 23, 26, 30, 32); however, there are limited reports concerning the antiviral activity against DNA viruses.”
- Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C (2009, background): “This gene and IL28A and IL29 (encoding IL-28A and IL-29, respectively) are three closely related cytokine genes that encode proteins known as type III IFNs (IFN-λs) and that form a cytokine gene cluster at chromosomal region 19q13 (ref”