TH1 cells control themselves by producing interleukin-10

By A. O’Garra, P. Vieira. Nature reviews. Immunology, 2007

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How researchers see this paper

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From Q Fever to Coxiella burnetii Infection: a Paradigm Change (2016, background): “Interleukin-10 levels are determinant in the clearance or the persistence of pathogens infecting humans (324, 325).”
Interleukin-10: new perspectives on an old cytokine (2008, background): “The four major T-cell sources of IL-10 are T-helper type 2 (Th2) cells, subsets of regulatory T cells designated Tr1, Th1, and Th17 cells (6).”
Macrophage activation by endogenous danger signals (2008, background): “IL-10 is an important anti-inflammatory cytokine that inhibits the synthesis and action of many inflammatory cytokines [3,4].”
Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset (2008, background): “The only T H 2-associated cytokine that continued to be expressed was IL-10, but this cytokine is not specific for T H 2 cells, as in certain conditions it is can also be expressed by T H 1 or T H -17 cell”
Immunomodulatory mast cells: negative, as well as positive, regulators of immunity (2008, background): “84 ), it will be of interest to assess whether mast cells and mast-cell-derived IL-10 have important effects on the number, phenotype and/or function of regulatory T cells in models of CHS or chronic UVB irradiation, or in other settings in which regulatory T cells are thought to have important role”