Coordination of circadian timing in mammals

By Steven M. Reppert, D. Weaver. Nature, 2002

4,420 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/9956d8b073936cd697cf200d6edb7debb6f073ce

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Endocrine and Autonomic Systems

In Physiology

Citations in the corpus

BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis (2004, background): “1994), transcription factors that compose the positive limb of an autoregulatory feedback loop in the core molecular clock (Young and Kay 2001; Reppert and Weaver 2002), also impairs circadian behavior.”
On the move around the clock: correlates and determinants of cathemeral activity in wild redfronted lemurs (Eulemur fulvus rufus) (2003, background): “The importance of the day-night cycle as the most effective Zeitgeber who phase sets the circadian rhythm to the environmental 24-h day has long been established in many other taxa (Aschoff 1960; see also Reppert and Weaver 2002), so that cathemeral lemurs are not unusual in this respect.”
Circadian regulator CLOCK is a histone acetyltransferase. (2006, positive): “The molecular framework of the circadian clock machinery is constituted by a network of transcription/translation-based autoregulatory feedback loops (Cermakian and Sassone-Corsi, 2000; Dunlap, 1999; King and Takahashi , 2000; Reppert and Weaver, 2002; Young and Kay, 2001).”
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “…while two cryptochrome (CRY) and three period proteins (PER) are involved in the negative control of the oscillator [Albrecht, 2002; DeBruyne et al., 2007a; DeBruyne et al., 2007b; Isojima et al., 2003; Reppert and Weaver, 2002; Schibler and Naef, 2005; Schibler and Sassone-Corsi, 2002] (Figure 8).”
Epigenetic mechanisms in memory formation (2005, background): “Circadian rhythms are generated endogenously by a biological timekeeping mechanism known as the circadian clock, which comprises intricate feedback loops of transcription and translatio”
What makes us tick? Functional and neural mechanisms of interval timing (2005, background): “This master clock coordinates tissue-specific rhythms according to light inpu”
System-level identification of transcriptional circuits underlying mammalian circadian clocks (2005, background): “Circadian rhythms are endogenous self-sustained oscillations with a period of ∼24 h that are manifested in diverse physiological and metabolic processe”
A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. (2004, background): “…the SCN is their requirement for normal rhythmic consoli-are reduced, these genes still appeared to retain some dation of locomotor activity (Reppert and Weaver, 2002).rhythmic expression, suggesting the influence of other Genetic defects in these components lead to alterationscircadian…”
The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. (2006, background): “In mammals, the circadian system is composed of a central pacemaker located in the hypothalamus and local oscillators in the peripheral tissues (Shearman et al., 2000; Reppert and Weaver, 2002; Schibler and Sassone-Corsi, 2002).”
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice (2005, background): “In just the past few years, two major developments have transformed our understanding of the circadian clock system in mammals: 1) the elucidation of the transcriptional-translational feedback loop(s) that drives cellular rhythms [2, 21], and 2) the discovery that circadian clocks are expressed in n”
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. (2008, positive): “The molecular oscillator in both master and subsidiary clocks (Balsalobre et al., 1998; Yagita et al., 2001) is thought to rely on a negative transcriptional feedback loop (Hardin et al., 1990; Lowrey and Takahashi, 2000; Reppert and Weaver, 2002).”
Control of Mammalian Circadian Rhythm by CKIε-Regulated Proteasome-Mediated PER2 Degradation (2005, background): “tagged mPer2, amino acid positions 1 to 904 [mPer2(1-904)], the above cDNA”