A functional genomics strategy reveals Rora as a component of the mammalian circadian clock.

By Trey K. Sato, Satchidananda Panda, L. Miraglia, T. Reyes, R. Rudic, P. McNamara, Kinnery Naik, G. FitzGerald, Steve A. Kay, John B. Hogenesch. Neuron, 2004

1,117 citations recorded by the source corpus.

Subfields: Aging, Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/d73c648eecbd194c9f0fa0a360e66ced2fcc1816

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. J. Takahashi
2. A. Jetten
3. U. Albrecht
4. F. Alt
5. C. Dibner
6. U. Schibler
7. R. Mostoslavsky
8. D. Virshup

In Endocrine and Autonomic Systems

1. J. Takahashi
2. U. Albrecht
3. C. H. Ko
4. A. Jetten
5. Ethan D. Buhr
6. Steve A. Kay
7. David K. Welsh
8. C. Dibner

In Plant Science

1. J. Takahashi
2. U. Albrecht
3. C. H. Ko
4. Ethan D. Buhr
5. A. Jetten
6. U. Schibler
7. C. Dibner
8. Steve A. Kay

Citations in the corpus

• Molecular components of the Mammalian circadian clock. (2013, background): “This involves the E-box-mediated transcription of the orphan nuclear-receptor genes Rev-Erbα/β and RORα/β (Preitner et al. 2002; Sato et al. 2004; Guillaumond et al. 2005).”
• Comprehensive integration of single-cell data (2018, positive): “Intriguingly, as with Mef2c , Rora also exhibits RNA upregulation in PV compared to SST interneurons (Figure 3H) and may also play function in fate specification.”
• Post-translational modifications regulate the ticking of the circadian clock (2007, positive): “Last, the core clock is stabilized by the opposing functions of the orphan nuclear receptors Rora and Rev-Erbα, which activate and repress Bmal1 expression, respectivel”
• Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “Mice deficient in RORα or RORβ exhibit an aberrant circadian behavior [Akashi and Takumi, 2005; Masana et al., 2007; Sato et al., 2004; Schaeren-Wiemers et al., 1997], while no abnormalities in circadian behavior have been noticed in RORγ-/- mice [Liu et al., 2008].”
• Timing to perfection: the biology of central and peripheral circadian clocks. (2012, background): “This organization is schematically repeated at the systems level where signals, such as light detected by the retina (input, external environment), are transmitted to the suprachiasmatic nuclei (SCN) (clock).”
• Differential Control of Bmal1 Circadian Transcription by REV-ERB and ROR Nuclear Receptors (2005, background): “In contrast to Rev-erbα, the peak of Rorα mRNA in the SCN precedes the rise of Bmal1 mRNA (Sato et al., 2004), consistent with a putative stimulating role of RORα in Bmal1 transcription.”
• Circadian genes, rhythms and the biology of mood disorders. (2007, background): “In addition, there is an adjoining loop in which CLOCK/BMAL1 activates the transcription of Rev-erbα and Rorα (Sato et al., 2004;Guillaumond et al., 2005).”
• Intercellular coupling confers robustness against mutations in the SCN circadian clock network. (2007, background): “Wheel-running is a complex rhythmic output confounded by association with feeding, phenotypic variability, and pleiotropy of the underlying gene mutation (Bucan and Abel, 2002; Sato et al., 2004; Lowrey and Takahashi, 2004).”