System-level identification of transcriptional circuits underlying mammalian circadian clocks

By Hiroki R. Ueda, S. Hayashi, Wenbin Chen, M. Sano, M. Machida, Y. Shigeyoshi, M. Iino, S. Hashimoto. Nature Genetics, 2005

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Post-translational modifications regulate the ticking of the circadian clock (2007, positive): “Remarkably, circadian oscillators are also present in all tissues of the body, where they are synchronized by unidentified signals to regulate, in a tissue-specific manner, transcriptional activity throughout the da”
Suprachiasmatic Nucleus: Cell Autonomy and Network Properties (2010, background): “Thus, the intracellular circadian timekeeper can be conceptualized as a genetic network, a web of interconnected negative feedback loops regulating transcription of core clock genes (2) and output genes.”
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “The promoter regulatory regions of several genes down-regulated in RORαsg/sg Purkinje cells, including those of Pcp2, Pcp4, Itpr1, Shh, and Slc1a6, contain ROREs that bind RORα [Gold et al., 2003; Gold et al., 2007; Serinagaoglu et al., 2007].”
Timing to perfection: the biology of central and peripheral circadian clocks. (2012, background): “Furthermore, D-box elements have been recognized as the third important factor that regulates circadian transcription (Ueda et al., 2005).”
CircaDB: a database of mammalian circadian gene expression profiles (2012, background): “The cAMP Responsive Element Binding Protein (CREB) pathway (8,9) and D-box binding factors, Dbp, Hlf, Tef, Nfil3, also regulate clock function (10,11).”