Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

By F. Turek, C. Joshu, A. Kohsaka, Emily Lin, Ganka Ivanova, Erin L. McDearmon, A. Laposky, S. Losee-Olson, A. Easton, D. Jensen and 3 more. Science, 2005

2,479 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/f3b74571eb5de8f85cac9f3339900cb2472b9388

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. J. Takahashi
2. U. Albrecht
3. A. Jetten

In Endocrine and Autonomic Systems

1. J. Takahashi
2. U. Albrecht
3. C. H. Ko
4. C. Green
5. J. Mohawk
6. C. Dibner
7. A. Jetten
8. U. Schibler

In Physiology

1. J. Takahashi
2. V. Samuel
3. U. Albrecht
4. C. Green
5. M. Qatanani
6. Gerald I. Shulman
7. Mitchell A. Lazar
8. C. H. Ko

Citations in the corpus

• Adverse metabolic and cardiovascular consequences of circadian misalignment (2009, background): “In some animal models, repeated shifts in the light/dark cycle—typical of shift work— leads to premature death, while mutations of circadian clock genes can lead to signs of metabolic syndrome (11, 26, 27), supporting the potential negative health consequences of circadian disturbances.”
• Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice (2010, background): “This is not a trivial point, as changes to circadian rhythms have been shown to affect glucose metabolism (Rudic et al., 2004; Turek et al., 2005; Kohsaka and Bass, 2007).”
• Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain (2013, result): “Our findings showing increased food intake despite changes in hormones that promote satiety/reduce hunger are consistent with findings from studies of clock mutant mice (34) and sleeprestricted ad libitum fed humans (21).”
• The mammalian circadian timing system: organization and coordination of central and peripheral clocks. (2010, background): “Mice with a mutation in the Clock gene display elevated leptin levels (177) and TH activity with increased dopamine levels in the VTA (143).”
• Metabolic regulation of epigenetics (2012, background): “Bmal1 / and Clockmut mice exhibit various abnormalities of glucose and lipid homeostasis (Oishi et al., 2006; Rudic et al., 2004; Turek et al., 2005).”
• The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control (2008, neutral): “, 2002; Schibler and Sassone-Corsi, 2002), and much compelling evidence has accumulated (Turek et al., 2005; Wijnen and Young, 2006).”
• Melatonin: a multitasking molecule. (2010, neutral): “(Erren and Reiter, 2009b; Turek et al., 2005).”
• Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. (2014, background): “The host circadian clock controls the rhythmicity of many physiological functions, including food consumption (Turek et al., 2005).”
• Time restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high fat diet (2012, neutral): “A number of mouse genetic models carrying wholebody- or tissue-specific perturbation of circadian oscillators (Cho et al., 2012; Kornmann et al., 2007; Lamia et al., 2008; Marcheva et al., 2010; Preitner et al., 2002; Turek et al., 2005) or key metabolic regulators (Andreelli et al.”