Circadian regulator CLOCK is a histone acetyltransferase.

By M. Doi, J. Hirayama, Paolo Sassone-Corsi. Cell, 2006

905 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/4896cdb56b5bb3a76e9718a9518d86a1971a1377

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In Endocrine and Autonomic Systems

In Plant Science

Citations in the corpus

Post-translational modifications regulate the ticking of the circadian clock (2007, positive): “and CLOCK itself possesses intrinsic histone acetyltransferase (HAT) activit”
Molecular components of the Mammalian circadian clock. (2013, background): “itself possesses a histone acetyl transferase (HAT) domain which is necessary for the rescue of rhythms in Clock-mutant fibroblasts (Doi et al. 2006).”
Physiology of circadian entrainment. (2010, background): “Alteration of chromatin structure is a fundamental step that gates transcription, and the molecular clock is not an exception, being regulated by several biochemical modifications such as histone acetylation among others (17, 112, 174, 175, 204, 360).”
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. (2008, neutral): “The enzyme(s) responsible for PER2 acetylation remain(s) to be identified, but the acetyltransferase activity of CLOCK (Doi et al., 2006) or p300, a coactivator associated with CLOCKBMAL1 heterodimer (Etchegaray et al.”
The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control (2008, neutral): “Intriguingly Sir2, a NAD+-dependent HDAC, had been functionally linked to Sas2 (Kimura et al., 2002; Suka et al., 2002), a protein of the MYST family of HATs to which CLOCK belongs (Doi et al., 2006; Nakahata et al., 2007).”
Histone acetyltransferase complexes: one size doesn't fit all (2007, background): “Most recently, the circadian rhythm protein CLOCK has also been described as having a MYST-like HAT domain, which is important for its functio”
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “CLOCK, which functions as a histone acetyltransferase, has been implicated in chromatin remodeling during circadian rhythm [Doi et al., 2006].”
The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (2008, background): “Interestingly, the CLOCK protein has been shown to possess histone acetyltransferase activit”
Molecular components of the mammalian circadian clock. (2006, background): “itself possesses a histone acetyl transferase (HAT) domain which is necessary for the rescue of rhythms in Clock-mutant fibroblasts (Doi et al. 2006).”